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深入分析实验室参数揭示了 COVID-19 患者中性别、年龄和全身炎症之间的相互作用。

In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19.

机构信息

Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, University of São Paulo, São Paulo, Brazil.

Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

出版信息

Int J Infect Dis. 2021 Apr;105:579-587. doi: 10.1016/j.ijid.2021.03.016. Epub 2021 Mar 10.

DOI:10.1016/j.ijid.2021.03.016
PMID:33713813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7944763/
Abstract

BACKGROUND

The progression and severity of COVID-19 vary significantly in the population. While the hallmarks of SARS-CoV-2 and severe COVID-19 within routine laboratory parameters are emerging, the impact of sex and age on these profiles is still unknown.

METHODS

A multidimensional analysis was performed involving millions of records of laboratory parameters and diagnostic tests for 178 887 individuals from Brazil, of whom 33 266 tested positive for SARS-CoV-2. Analyzed data included those relating to complete blood cell count, electrolytes, metabolites, arterial blood gases, enzymes, hormones, cancer biomarkers, and others.

FINDINGS

COVID-19 induced similar alterations in laboratory parameters in males and females. CRP and ferritin were increased, especially in older men with COVID-19, whereas abnormal liver function tests were common across several age groups, except for young women. Low peripheral blood basophils and eosinophils were more common in the elderly with COVID-19. Both male and female COVID-19 patients admitted to intensive care units displayed alterations in the coagulation system, and higher values for neutrophils, CRP, and lactate dehydrogenase.

CONCLUSIONS

Our study uncovered the laboratory profiles of a large cohort of COVID-19 patients, which formed the basis of discrepancies influenced by aging and biological sex. These profiles directly linked COVID-19 disease presentation to an intricate interplay between sex, age, and immune activation.

摘要

背景

COVID-19 在人群中的进展和严重程度差异很大。虽然 SARS-CoV-2 和常规实验室参数中的严重 COVID-19 的特征正在显现，但性别和年龄对这些特征的影响仍不清楚。

方法

对来自巴西的 178878 名个体的数百万份实验室参数和诊断测试记录进行了多维分析，其中 33266 人检测出 SARS-CoV-2 呈阳性。分析的数据包括全血细胞计数、电解质、代谢物、动脉血气、酶、激素、癌症生物标志物等相关数据。

结果

COVID-19 在男性和女性中引起相似的实验室参数改变。CRP 和铁蛋白升高，尤其是患有 COVID-19 的老年男性，而异常肝功能试验在多个年龄组中很常见，除了年轻女性。COVID-19 老年患者外周血嗜碱性粒细胞和嗜酸性粒细胞减少。入住重症监护病房的 COVID-19 男女患者的凝血系统均发生改变，中性粒细胞、CRP 和乳酸脱氢酶值升高。

结论

本研究揭示了大量 COVID-19 患者的实验室特征，这些特征是由衰老和生物性别影响的差异所构成的基础。这些特征将 COVID-19 疾病表现与性别、年龄和免疫激活之间的复杂相互作用直接联系起来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7959/7944763/a4007e36d538/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7959/7944763/a3f7f070c81f/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7959/7944763/e29fddc39c2b/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7959/7944763/efc7fa935582/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7959/7944763/b422efa1c6fc/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7959/7944763/a4007e36d538/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7959/7944763/a3f7f070c81f/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7959/7944763/e29fddc39c2b/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7959/7944763/efc7fa935582/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7959/7944763/b422efa1c6fc/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7959/7944763/a4007e36d538/gr5_lrg.jpg

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2
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Clin Infect Dis. 2021 May 4;72(9):e240-e248. doi: 10.1093/cid/ciaa1022.
3
Cytokine storm syndrome in coronavirus disease 2019: A narrative review.
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Anal Bioanal Chem. 2024 Dec 23. doi: 10.1007/s00216-024-05706-x.
4
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Brain Behav Immun Health. 2024 Jun 13;39:100805. doi: 10.1016/j.bbih.2024.100805. eCollection 2024 Aug.
5
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6
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7
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