School of Basic Medical Sciences, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.
ACS Biomater Sci Eng. 2021 Mar 8;7(3):806-816. doi: 10.1021/acsbiomaterials.9b01818. Epub 2020 Aug 18.
The fabrication of scaffolds that precisely mimic the natural structure and physiochemical properties of bone is still one of the most challenging tasks in bone tissue engineering. 3D printing techniques have drawn increasing attention due to their ability to fabricate scaffolds with complex structures and multiple bioinks. For bone tissue engineering, lithography-based 3D bioprinting is frequently utilized due to its printing speed, mild printing process, and cost-effective benefits. In this review, lithography-based 3D bioprinting technologies including SLA and DLP are introduced; their typical applications in biological system and bioinks are also explored and summarized. Furthermore, we discussed possible evolution of the hardware/software systems and bioinks of lithography-based 3D bioprinting, as well as their future applications.
制造精确模拟骨的天然结构和理化特性的支架仍然是骨组织工程中最具挑战性的任务之一。由于能够制造具有复杂结构和多种生物墨水的支架,3D 打印技术引起了越来越多的关注。对于骨组织工程,基于光刻的 3D 生物打印由于其打印速度快、打印过程温和以及具有成本效益而经常被使用。在本综述中,介绍了基于光刻的 3D 生物打印技术,包括 SLA 和 DLP;还探索和总结了它们在生物系统和生物墨水中的典型应用。此外,我们还讨论了基于光刻的 3D 生物打印的硬件/软件系统和生物墨可能的发展,以及它们的未来应用。