Xu Yanchao, Wang Yong, Wu Dan, He Wenwen, Wang Liping, Zhu Weiming
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Front Microbiol. 2021 Feb 25;12:654963. doi: 10.3389/fmicb.2021.654963. eCollection 2021.
One new () and fifteen known (-) -terphenyls were isolated from a solid culture of the endophytic fungus sp. GZWMJZ-055 by adding the leaves of its host . Furthermore, nine -terphenyls (-) were synthesized from the main compounds (-), among which derivatives , , , , and are new -terphenyls. Compounds and were also, respectively, synthesized from compounds and by oxidative cyclization of air in the presence of silica gel. These -terphenyls especially those with 4,2',4″-trihydroxy (-, , ) or 4, 4″-dihydroxy-1,2,1',2'-furan (, ) substituted nucleus, exhibited significant antioxidant and α-glucosidase inhibitory activities and lower cytotoxicity to caco-2 cells. The results indicated their potential use as lead compounds or dietary supplements for treating or preventing the diabetes.
通过添加其宿主植物的叶子，从内生真菌 sp. GZWMJZ - 055 的固体培养物中分离出一种新的（）和十五种已知的（-）-三联苯。此外，从主要化合物（-）合成了九种 - 三联苯（-），其中衍生物 、、、、和 是新的 - 三联苯。化合物 和 也分别通过在硅胶存在下空气的氧化环化反应由化合物 和 合成。这些 - 三联苯，特别是那些具有 4,2',4″ - 三羟基（-、、）或 4, 4″ - 二羟基 - 1,2,1',2'- 呋喃（、）取代核的化合物，表现出显著的抗氧化和α - 葡萄糖苷酶抑制活性，并且对caco - 2细胞的细胞毒性较低。结果表明它们作为治疗或预防糖尿病的先导化合物或膳食补充剂的潜在用途。
