-Terphenyls From sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities.

One new () and fifteen known (-) -terphenyls were isolated from a solid culture of the endophytic fungus sp. GZWMJZ-055 by adding the leaves of its host . Furthermore, nine -terphenyls (-) were synthesized from the main compounds (-), among which derivatives , , , , and are new -terphenyls. Compounds and were also, respectively, synthesized from compounds and by oxidative cyclization of air in the presence of silica gel. These -terphenyls especially those with 4,2',4″-trihydroxy (-, , ) or 4, 4″-dihydroxy-1,2,1',2'-furan (, ) substituted nucleus, exhibited significant antioxidant and α-glucosidase inhibitory activities and lower cytotoxicity to caco-2 cells. The results indicated their potential use as lead compounds or dietary supplements for treating or preventing the diabetes.