Ozsvar Jazmin, Yang Chengeng, Cain Stuart A, Baldock Clair, Tarakanova Anna, Weiss Anthony S
Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.
Front Bioeng Biotechnol. 2021 Feb 25;9:643110. doi: 10.3389/fbioe.2021.643110. eCollection 2021.
Elastic fibers are an important component of the extracellular matrix, providing stretch, resilience, and cell interactivity to a broad range of elastic tissues. Elastin makes up the majority of elastic fibers and is formed by the hierarchical assembly of its monomer, tropoelastin. Our understanding of key aspects of the assembly process have been unclear due to the intrinsic properties of elastin and tropoelastin that render them difficult to study. This review focuses on recent developments that have shaped our current knowledge of elastin assembly through understanding the relationship between tropoelastin's structure and function.
弹性纤维是细胞外基质的重要组成部分，为多种弹性组织提供伸展性、弹性和细胞相互作用能力。弹性蛋白构成了弹性纤维的大部分，由其单体原弹性蛋白通过分级组装形成。由于弹性蛋白和原弹性蛋白的内在特性使其难以研究，我们对组装过程关键方面的理解一直不明确。本综述重点关注通过理解原弹性蛋白的结构与功能之间的关系，从而形成我们目前对弹性蛋白组装认识的最新进展。
