Department of Anatomy, Biomedical Sciences Institute, University of Sao Paulo, Avenue Lineu Prestes 2415, Room 007, Sao Paulo, SP, 05508-900, Brazil.
Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Photochem Photobiol Sci. 2021 Feb;20(2):293-301. doi: 10.1007/s43630-021-00018-w. Epub 2021 Feb 18.
There is no effective treatment to halt peripheral nervous system damage in diabetic peripheral neuropathy. Mitochondria have been at the center of discussions as important factors in the development of neuropathy in diabetes. Photobiomodulation has been gaining clinical acceptance as it shows beneficial effects on a variety of nervous system disorders. In this study, the effects of photobiomodulation (904 nm, 45 mW, 6.23 J/cm, 0.13 cm, 60 ns pulsed time) on mitochondrial dynamics were evaluated in an adult male rat experimental model of streptozotocin-induced type 1 diabetes. Results presented here indicate that photobiomodulation could have an important role in preventing or reversing mitochondrial dynamics dysfunction in the course of peripheral nervous system damage in diabetic peripheral neuropathy. Photobiomodulation showed its effects on modulating the protein expression of mitofusin 2 and dynamin-related protein 1 in the sciatic nerve and in the dorsal root ganglia neurons of streptozotocin-induced type 1 diabetes in rats.
目前，对于糖尿病周围神经病变导致的周围神经系统损伤，尚无有效的治疗方法。线粒体一直是糖尿病相关神经病变发展过程中的重要因素之一。由于光生物调节在多种神经系统疾病中显示出有益的作用，因此已逐渐在临床上得到认可。在这项研究中，我们评估了光生物调节（904nm、45mW、6.23J/cm、0.13cm、60ns 脉冲时间）对链脲佐菌素诱导的 1 型糖尿病雄性成年大鼠实验模型中线粒体动力学的影响。这里呈现的结果表明，光生物调节可能在预防或逆转糖尿病周围神经病变中周围神经系统损伤过程中线粒体动力学功能障碍方面发挥重要作用。光生物调节对调节 1 型糖尿病大鼠坐骨神经和背根神经节神经元中线粒体融合蛋白 2 和动力相关蛋白 1 的蛋白表达有影响。
