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自体血小板组织移植在角膜屈光手术后伤口愈合中的益处:一例报告

Benefits of autologous platelet tissue graft in wound healing after corneal refractive surgery: a case report.

作者信息

Takayanagi Yoshinori, Kato Shigeaki, Okada Masaru

机构信息

Takayanagi EYE Clinic, Sapporo S1 Building 3F, Nishi4-20-5, Minami1-jo, Chuo-ku, Sapporo, Hokkaido, 060-0807, Japan.

Graduate School of Science and Engineering, Iryo Sosei University, 5-5-1, Iino, Chuo-dai, Iwaki, Fukushima, 970-8551, Japan.

出版信息

J Med Case Rep. 2021 Mar 16;15(1):122. doi: 10.1186/s13256-021-02694-9.

Abstract

BACKGROUND

Corneal refractive surgeries cause epithelial damage and induce wound healing processes. To promote wound healing after photorefractive keratectomy, the effectiveness of an autologous platelet tissue graft was assessed.

CASE PRESENTATION

A 45-year-old Asian male with low myopia and/or myopic astigmatism received photorefractive keratectomy in both eyes. The right eye was postoperatively treated with an autologous platelet tissue graft using the GPS III Platelet Concentration System to prepare platelet-rich plasma, while the left eye was not treated. Both eyes achieved the expected uncorrected distance visual acuity, but the platelet-rich-plasma-treated right eye obtained improved visual acuity more than 1 week before the untreated left eye. Perceived pain after photorefractive keratectomy was much lower and of shorter duration in the treated right eye than it was for the left eye. Pericorneal injection on the bulbar conjunctiva with superficial keratitis resolved earlier in the right eye than the left eye.

CONCLUSIONS

Autologous platelet tissue grafting using a GPS III to obtain platelet-rich plasma was effective in promoting corneal wound healing after photorefractive keratectomy. Thus, platelet-rich plasma may be beneficial for patients undergoing corneal refractive surgeries.

摘要

背景

角膜屈光手术会导致上皮损伤并引发伤口愈合过程。为促进准分子激光角膜切削术后的伤口愈合,评估了自体血小板组织移植的有效性。

病例报告

一名45岁患有低度近视和/或近视散光的亚洲男性双眼接受了准分子激光角膜切削术。右眼术后使用GPS III血小板浓缩系统制备富含血小板血浆进行自体血小板组织移植治疗,而左眼未进行治疗。双眼均达到预期的未矫正远视力,但接受富含血小板血浆治疗的右眼比未治疗的左眼提前1周以上获得了视力改善。准分子激光角膜切削术后,治疗的右眼比左眼的感知疼痛更低且持续时间更短。右眼球结膜角膜周围注射伴浅层角膜炎的消退比左眼更早。

结论

使用GPS III获取富含血小板血浆的自体血小板组织移植在促进准分子激光角膜切削术后角膜伤口愈合方面是有效的。因此,富含血小板血浆可能对接受角膜屈光手术的患者有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04e2/7962214/1acf8e05a518/13256_2021_2694_Fig1_HTML.jpg

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