School of Computer Engineering, Institute of Engineering, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Department of Computer Science, Faculty of Informatics, Burapha University, Chon Buri, Thailand.
Sci Rep. 2021 Mar 17;11(1):6106. doi: 10.1038/s41598-021-85436-7.
Segmenting a liver and its peripherals from abdominal computed tomography is a crucial step toward computer aided diagnosis and therapeutic intervention. Despite the recent advances in computing methods, faithfully segmenting the liver has remained a challenging task, due to indefinite boundary, intensity inhomogeneity, and anatomical variations across subjects. In this paper, a semi-automatic segmentation method based on multivariable normal distribution of liver tissues and graph-cut sub-division is presented. Although it is not fully automated, the method minimally involves human interactions. Specifically, it consists of three main stages. Firstly, a subject specific probabilistic model was built from an interior patch, surrounding a seed point specified by the user. Secondly, an iterative assignment of pixel labels was applied to gradually update the probabilistic map of the tissues based on spatio-contextual information. Finally, the graph-cut model was optimized to extract the 3D liver from the image. During post-processing, overly segmented nodal regions due to fuzzy tissue separation were removed, maintaining its correct anatomy by using robust bottleneck detection with adjacent contour constraint. The proposed system was implemented and validated on the MICCAI SLIVER07 dataset. The experimental results were benchmarked against the state-of-the-art methods, based on major clinically relevant metrics. Both visual and numerical assessments reported herein indicated that the proposed system could improve the accuracy and reliability of asymptomatic liver segmentation.
从腹部计算机断层扫描中分割肝脏及其周围组织是计算机辅助诊断和治疗干预的关键步骤。尽管计算方法最近取得了进展,但由于边界不确定、强度不均匀以及个体之间的解剖差异,准确分割肝脏仍然是一项具有挑战性的任务。本文提出了一种基于肝脏组织多变量正态分布和图割细分的半自动分割方法。虽然它不是完全自动化的,但该方法最少需要人工交互。具体来说,它包括三个主要阶段。首先,从用户指定的种子点周围的内部斑块构建针对特定主体的概率模型。其次,应用迭代像素标签分配,根据空间上下文信息逐步更新组织的概率图。最后,优化图割模型以从图像中提取 3D 肝脏。在后处理过程中,由于组织分离模糊而导致过度分割的节点区域被删除,通过使用具有相邻轮廓约束的稳健瓶颈检测来保持其正确的解剖结构。该系统在 MICCAI SLIVER07 数据集上实现并验证。根据主要的临床相关指标,将实验结果与最先进的方法进行了基准测试。本文报告的视觉和数值评估表明,该系统可以提高无症状肝脏分割的准确性和可靠性。
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