Harmon Caroline P, Deng Daiyong, Breslin Paul A S
Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Curr Opin Physiol. 2021 Apr;20:70-76. doi: 10.1016/j.cophys.2021.01.006. Epub 2021 Jan 12.
In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate endocrine, behavioral, and immunological responses. T2R agonists include indicators of incoming threats to metabolic homeostasis, pathogens, and irritants. This review will provide an overview of T2R-regulated processes throughout the body that function defensively. We propose a broader definition of T2Rs as chemosensory sentinels that monitor toxic, metabolic, and infectious threats and initiate defensive responses.
除了负责苦味感知外，2型味觉受体（T2Rs）还调节内分泌、行为和免疫反应。T2R激动剂包括对代谢稳态、病原体和刺激物的潜在威胁指标。本综述将概述T2R在全身调节的防御性功能过程。我们提出了一个更广泛的T2Rs定义，即作为化学感应哨兵监测有毒、代谢和感染性威胁并启动防御反应。
