Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Sleep Breath. 2021 Dec;25(4):2277-2285. doi: 10.1007/s11325-021-02338-8. Epub 2021 Mar 18.
To investigate the associations between sleep duration and atherosclerotic cardiovascular disease (ASCVD) risk and the potential mechanism.
Overall, 24,471 subjects without ASCVD were included from Dongfeng-Tongji (DFTJ) cohort. Data collection included questionnaires and general medical examinations. We used logistic regression models and generalized linear models to examine the associations between sleep duration, peripheral white blood cell (WBC) counts, and 10-year ASCVD risk. Mediation analyses were further performed to assess the potential role of peripheral WBC counts in the associations between sleep duration and 10-year ASCVD risk.
Increased risk of 10-year ASCVD was observed as sleep duration extended. After adjusting for potential confounders, the odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of 10-year ASCVD were 1.24 (1.11-1.38), 1.12 (1.03-1.22), and 1.21(1.08-1.36) for individuals with nighttime sleeping duration of ≥ 9 h, daytime napping duration of > 30 min, and daily sleep duration of ≥ 9 h, respectively. Peripheral WBC counts mediated 14.1%, 14.5%, and 12.6% in the associations of nighttime sleep duration of ≥ 9 h, daytime napping duration of > 30 min and daily sleep duration of ≥ 9 h with 10-year ASCVD risk, respectively.
Extended sleep durations are associated with the increased 10-year ASCVD risk, and the associations are partially mediated by peripheral WBC counts.
探讨睡眠时长与动脉粥样硬化性心血管疾病（ASCVD）风险的关联及其潜在机制。
本研究纳入了来自东风-同济队列的 24471 例无 ASCVD 的受试者。数据收集包括问卷调查和一般体格检查。我们使用逻辑回归模型和广义线性模型来检验睡眠时长、外周血白细胞（WBC）计数与 10 年 ASCVD 风险之间的关联。进一步进行中介分析以评估外周血 WBC 计数在睡眠时长与 10 年 ASCVD 风险关联中的潜在作用。
随着睡眠时长的延长，10 年 ASCVD 风险增加。在调整了潜在混杂因素后，夜间睡眠时间≥9 小时、日间小睡时间>30 分钟和每日总睡眠时间≥9 小时的个体发生 10 年 ASCVD 的风险比（OR）及其 95%置信区间（CI）分别为 1.24（1.11-1.38）、1.12（1.03-1.22）和 1.21（1.08-1.36）。外周血 WBC 计数分别介导了夜间睡眠时间≥9 小时、日间小睡时间>30 分钟和每日总睡眠时间≥9 小时与 10 年 ASCVD 风险关联的 14.1%、14.5%和 12.6%。
延长的睡眠时间与 10 年 ASCVD 风险增加相关，这种关联部分通过外周血 WBC 计数介导。
