Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China.
Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Adv Exp Med Biol. 2021;1316:41-47. doi: 10.1007/978-981-33-6785-2_3.
The tumor microenvironment represents the dynamic network consisting of tumor cells, stromal cells, and multiple lineages of immune subsets. It is well recognized that metabolic crosstalk within the tumor microenvironment (TME) greatly shapes both the composition and functionality of the infiltrated immune cells and therefore critically regulate the antitumor immunity. In general, most solid tumors are considered as lipid-enriched environment, which is beneficial for tumor cell growth and immune escape. Here we briefly summarize the effects of accumulated lipids on tumor cells and immune cells. We also discuss the possibility of targeting lipid metabolism within the TME and potential strategies for optimizing cancer treatment.
肿瘤微环境代表了由肿瘤细胞、基质细胞和多种免疫亚群组成的动态网络。人们已经认识到，肿瘤微环境（TME）中的代谢串扰极大地影响了浸润免疫细胞的组成和功能，因此对肿瘤免疫具有重要的调节作用。一般来说，大多数实体瘤被认为是富含脂质的环境，有利于肿瘤细胞的生长和免疫逃避。在这里，我们简要总结了积累的脂质对肿瘤细胞和免疫细胞的影响。我们还讨论了靶向 TME 中脂质代谢的可能性和优化癌症治疗的潜在策略。
