Department of Internal Medicine, The Affiliated Third Hospital of Jiangsu University, Zhenjiang, China.
Department of Radiology, The Affiliated Third Hospital of Jiangsu University, Zhenjiang, China.
Aging (Albany NY). 2021 Mar 21;13(8):11096-11119. doi: 10.18632/aging.202765.
Although a previous pan-cancer study has reported the expression patterns of in various tumors, their analyses have been restricted to limited cancer types. We thus comprehensively analyzed the expression profiles and clinical significances of in a broader spectrum of cancers from TCGA. Our results showed that were primarily down-regulated in tested cancers. The members were associated with either survival advantage or disadvantage, depending on the cancer type tested and the genes queried. Importantly, we for the first time demonstrated that had substantially decreased expression in liver hepatocellular carcinoma (LIHC) compared with corresponding normal tissue, and its down-regulation adversely impacted patient outcome. Moreover, expression was consistently declining during the progression of LIHC. Further analysis revealed that may be involved in cellular metabolic processes. Our findings established as a potential diagnostic and prognostic biomarker for LIHC, which awaits future experimental validation.
虽然之前的泛癌症研究已经报道了在各种肿瘤中的表达模式，但它们的分析仅限于有限的癌症类型。因此，我们从 TCGA 中全面分析了更广泛的癌症中 的表达谱和临床意义。我们的结果表明，在测试的癌症中，主要下调了 。取决于测试的癌症类型和查询的基因，成员与生存优势或劣势相关。重要的是，我们首次证明与相应的正常组织相比，在肝癌（LIHC）中 表达显著降低，其下调会对患者的预后产生不利影响。此外，在 LIHC 的进展过程中， 的表达持续下降。进一步的分析表明， 可能参与细胞代谢过程。我们的研究结果确立了 作为 LIHC 的潜在诊断和预后生物标志物，有待进一步的实验验证。
