Blazkova Jana, Huiting Erin D, Boddapati Arun Kumar, Shi Victoria, Whitehead Emily J, Justement Jesse S, Nordstrom Jeffrey L, Moir Susan, Lack Justin, Chun Tae-Wook
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
NIAID Collaborative Bioinformatics Resource, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
J Infect Dis. 2021 Nov 16;224(9):1599-1604. doi: 10.1093/infdis/jiab155.
Persistent exposure to antigen leads to T-cell exhaustion and immunologic dysfunction. We examined the immune exhaustion markers T cell immunoglobulin and ITIM domain (TIGIT) and programmed cell death protein 1 (PD-1) in human immunodeficiency virus (HIV)-infected and healthy individuals and the relationship with cytotoxic CD8+ T-lymphocyte activity. Frequencies of TIGIT but not PD-1 were positively correlated with CD8+ T-lymphocyte activity in HIV-aviremic and healthy individuals; however, there was no correlation in HIV-viremic individuals. Transcriptome analyses revealed up-regulation of genes associated with antiviral immunity in TIGIT+CD8+ versus TIGIT-CD8+ T cells. Our data suggest that TIGIT+CD8+ T cells do not necessarily represent a state of immune exhaustion and maintain an intrinsic cytotoxicity in HIV-infected individuals.
持续暴露于抗原会导致T细胞耗竭和免疫功能障碍。我们检测了人类免疫缺陷病毒（HIV）感染者和健康个体中的免疫耗竭标志物T细胞免疫球蛋白和ITIM结构域（TIGIT）以及程序性细胞死亡蛋白1（PD - 1），并研究了它们与细胞毒性CD8 + T淋巴细胞活性的关系。在HIV病毒血症阴性和健康个体中，TIGIT的频率而非PD - 1的频率与CD8 + T淋巴细胞活性呈正相关；然而，在HIV病毒血症阳性个体中则无相关性。转录组分析显示，与TIGIT - CD8 + T细胞相比，TIGIT + CD8 + T细胞中与抗病毒免疫相关的基因上调。我们的数据表明，TIGIT + CD8 + T细胞不一定代表免疫耗竭状态，并且在HIV感染个体中维持内在的细胞毒性。
