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打破平衡:印度全国性孕妇营养补充计划在降低低出生体重儿和新生儿死亡率方面的作用。

Tipping the scale: the role of a national nutritional supplementation programme for pregnant mothers in reducing low birth weight and neonatal mortality in India.

机构信息

Society for Health and Demographic Surveillance, Suri731101, WB, India.

Department of Global Health and Population, Harvard T H Chan School of Public Health, Boston, MA02115, USA.

出版信息

Br J Nutr. 2022 Jan 28;127(2):289-297. doi: 10.1017/S0007114521000982. Epub 2021 Mar 22.

DOI:10.1017/S0007114521000982
PMID:33745458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8756072/
Abstract

With over 1·3 million Anganwadi centres (AWC) (meaning 'courtyard shelter'), the Indian government runs a nationwide intervention providing nutrition supplement to pregnant mothers to improve the health of their children. Using two successive rounds of the nationally representative cross-sectional National Family Health Survey data (collected during 2005-2006 and 2015-2016) of India, we assessed whether nutrition supplements given to pregnant mothers through AWC were associated with select child health indicators - extremely low birth weight (ELBW), very low birth weight (VLBW), low birth weight (LBW) and neonatal mortality (death during day 0-27) stratified by death during day 0-1, day 2-6 and day 7-27. A total of 148 019 children and 205 593 children were eligible for analysing birth weight and neonatal mortality, respectively. OR with 95% CI, estimated from multivariate logistic regression models, suggest that receipt of nutrition supplements was associated with decreased risk of VLBW (OR: 0·73, 95% CI 0·63, 0·83, P < 0·001), LBW (OR: 0·92, 95% CI 0·88, 0·96, P < 0·001), but not ELBW (OR: 0·80, 95% CI 0·56, 1·15, P = 0·226). Women who always received nutrition supplements during their pregnancy saw lower risk of death of their neonates (OR: 0·67, 95% CI 0·61, 0·73, P < 0·001), including death on day 0-1 (OR: 0·66, 95% CI 0·58, 0·74, P < 0·001), day 2-6 (OR: 0·69, 95% CI 0·58, 0·82, P < 0·001) and day 7-27 (OR: 0·68, 95% CI 0·53, 0·87, P = 0·002). Therefore, nutritional supplementation to pregnant mothers appears to be helpful in deterring various stages of neonatal mortality, VLBW and LBW, though it might not be effective in mitigating ELBW. Findings were discussed considering possible limitations of the study.

摘要

印度政府通过超过 130 万个安格旺迪中心(AWC)(意为“庭院庇护所”)提供全国性干预措施,为孕妇提供营养补充剂,以改善儿童健康。利用两轮全国代表性的横向国家家庭健康调查数据(分别在 2005-2006 年和 2015-2016 年收集),我们评估了通过 AWC 向孕妇提供的营养补充剂是否与某些儿童健康指标相关,包括极低出生体重(ELBW)、极低出生体重(VLBW)、低出生体重(LBW)和新生儿死亡率(出生后 0-27 天死亡),并按出生后 0-1 天、2-6 天和 7-27 天分层。共有 148019 名儿童和 205593 名儿童分别符合分析出生体重和新生儿死亡率的条件。多元逻辑回归模型估计的比值比(OR)及其 95%置信区间(CI)表明,接受营养补充剂与降低 VLBW(OR:0.73,95%CI:0.63,0.83,P < 0.001)、LBW(OR:0.92,95%CI:0.88,0.96,P < 0.001)的风险相关,但与 ELBW 无关(OR:0.80,95%CI:0.56,1.15,P = 0.226)。在怀孕期间一直接受营养补充剂的女性,其新生儿死亡的风险较低(OR:0.67,95%CI:0.61,0.73,P < 0.001),包括出生后 0-1 天(OR:0.66,95%CI:0.58,0.74,P < 0.001)、2-6 天(OR:0.69,95%CI:0.58,0.82,P < 0.001)和 7-27 天(OR:0.68,95%CI:0.53,0.87,P = 0.002)。因此,向孕妇提供营养补充似乎有助于阻止新生儿死亡、VLBW 和 LBW 的各个阶段,但可能无法减轻 ELBW。在考虑研究的可能局限性的情况下,对调查结果进行了讨论。

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Ann Epidemiol. 2020 Oct;50:7-14. doi: 10.1016/j.annepidem.2020.08.001. Epub 2020 Aug 12.
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