Khan Ranjha, Jiang Xiaohua, Hameed Uzma, Shi Qinghua
First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Genetics and Development, University of Science and Technology of China, Hefei, China.
Institute of Industrial Biotechnology, Government College University, Lahore, Pakistan.
Front Cell Dev Biol. 2021 Mar 5;9:639704. doi: 10.3389/fcell.2021.639704. eCollection 2021.
It has been found that the quality of oocytes from obese women has been compromised and subsequent embryos displayed arrested development. The compromised quality may be either due to the poor or rich metabolic conditions such as imbalance or excession of lipids during oocyte development. Generally, lipids are mainly stored in the form of lipid droplets and are an important source of energy metabolism. Similarly, lipids are also essential signaling molecules involved in various biological cascades of oocyte maturation, growth and oocyte competence acquisition. To understand the role of lipids in controlling the oocyte development, we have comprehensively and concisely reviewed the literature and described the role of lipid metabolism in oocyte quality and maturation. Moreover, we have also presented a simplified model of fatty acid metabolism along with its implication on determining the oocyte quality and cryopreservation for fertilization.
研究发现，肥胖女性的卵母细胞质量受损，随后的胚胎显示出发育停滞。质量受损可能是由于卵母细胞发育过程中代谢状况不佳或丰富，如脂质失衡或过量。一般来说，脂质主要以脂滴的形式储存，是能量代谢的重要来源。同样，脂质也是参与卵母细胞成熟、生长和卵母细胞能力获得的各种生物级联反应的重要信号分子。为了了解脂质在控制卵母细胞发育中的作用，我们全面且简要地回顾了文献，并描述了脂质代谢在卵母细胞质量和成熟中的作用。此外，我们还提出了一个脂肪酸代谢的简化模型及其对确定卵母细胞质量和冷冻保存用于受精的影响。
