用于神经退行性变和血脑屏障完整性的脑脊液生物标志物中的性别差异。
Sex differences in CSF biomarkers for neurodegeneration and blood-brain barrier integrity.
作者信息
Skillbäck Tobias, Blennow Kaj, Zetterberg Henrik, Shams Sara, Machado Alejandra, Pereira Joana, Lindberg Olof, Mielke Michelle M, Zettergren Anna, Ryden Lina, Westman Eric, Wahlund Lars-Olof, Skoog Ingmar, Kern Silke
机构信息
Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden.
Neuropsychiatric Epidemiology Unit Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy Centre for Ageing and Health (AgeCap) at the University of Gothenburg Sweden.
出版信息
Alzheimers Dement (Amst). 2021 Mar 17;13(1):e12141. doi: 10.1002/dad2.12141. eCollection 2021.
INTRODUCTION
As cerebrospinal fluid (CSF) neurofilament light protein (NfL) and the CSF/serum albumin ratio (Q) are used in the clinical routine, the impact of demographic factors on these biomarkers is important to understand.
METHODS
Participants were derived from two Swedish samples: the population-based H70 Study (n = 308, age 70) and a clinical routine cohort (CSF NfL, n = 8995, Q, n = 39252, age 0 to 95). In the population-based study, Q and NfL were examined in relation to sex, cardiovascular risk factors, and cerebral white matter lesions (WMLs). In the clinical cohort, Q and NfL sex differences were tested in relation to age.
RESULTS
Men had higher Q and NfL concentrations and had higher Q and NfL concentrations from adolescence throughout life. NfL was not related to WML, but Q correlated positively with WMLs.
DISCUSSION
The CSF NfL sex difference could not be explained by vascular pathology. Future studies should consider using different reference limits for men and women.
引言
由于脑脊液（CSF）神经丝轻链蛋白（NfL）和脑脊液/血清白蛋白比值（Q）已应用于临床常规检查，了解人口统计学因素对这些生物标志物的影响很重要。
方法
参与者来自两个瑞典样本：基于人群的H70研究（n = 308，年龄70岁）和一个临床常规队列（CSF NfL，n = 8995，Q，n = 39252，年龄0至95岁）。在基于人群的研究中，研究了Q和NfL与性别、心血管危险因素和脑白质病变（WMLs）的关系。在临床队列中，测试了Q和NfL的性别差异与年龄的关系。
结果
男性的Q和NfL浓度较高，并且从青春期到成年期都有较高的Q和NfL浓度。NfL与WML无关，但Q与WML呈正相关。
讨论
脑脊液NfL的性别差异无法用血管病理学来解释。未来的研究应考虑对男性和女性使用不同的参考限值。
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