Dittrich Anna, Ashton Nicholas J, Zetterberg Henrik, Blennow Kaj, Simrén Joel, Geiger Fiona, Zettergren Anna, Shams Sara, Machado Alejandra, Westman Eric, Schöll Michael, Skoog Ingmar, Kern Silke
Department of Neuropsychiatric Epidemiology Unit Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Department of Psychiatry Cognition and Old Age Psychiatry Sahlgrenska University Hospital Mölndal Sweden.
Alzheimers Dement (Amst). 2022 Mar 5;14(1):e12295. doi: 10.1002/dad2.12295. eCollection 2022.
Neurofilament light protein (NfL) in cerebrospinal fluid (CSF) and plasma (P) are suggested to be interchangeable markers of neurodegeneration. However, evidence is scarce from community-based samples. NfL was examined in a small-scale sample of 287 individuals from the Gothenburg H70 Birth cohort 1944 study, using linear models in relation to CSF and magnetic resonance imaging (MRI) biomarker evidence of neurodegeneration. CSF-NfL and P-NfL present distinct associations with biomarker evidence of Alzheimer's disease (AD) pathology and neurodegeneration. P-NfL was associated with several markers that are characteristic of AD, including smaller hippocampal volumes, amyloid beta (Aβ), Aβ, and Aβ/t-tau (total tau). CSF-NfL demonstrated associations with measures of synaptic and neurodegeneration, including t-tau, phosphorylated tau (p-tau), and neurogranin. Our findings suggest that P-NfL and CSF-NfL may exert different effects on markers of neurodegeneration in a small-scale community-based sample of 70-year-olds.
脑脊液（CSF）和血浆（P）中的神经丝轻链蛋白（NfL）被认为是神经退行性变的可互换标志物。然而，基于社区样本的相关证据却很少。在一项针对1944年哥德堡H70出生队列研究中287名个体的小规模样本中检测了NfL，采用线性模型分析其与脑脊液及神经退行性变的磁共振成像（MRI）生物标志物证据之间的关系。脑脊液NfL和血浆NfL与阿尔茨海默病（AD）病理及神经退行性变的生物标志物证据存在不同的关联。血浆NfL与AD的几种特征性标志物相关，包括较小的海马体积、β淀粉样蛋白（Aβ）、Aβ以及Aβ/总tau蛋白（t-tau）。脑脊液NfL与突触和神经退行性变的指标相关，包括t-tau、磷酸化tau蛋白（p-tau）和神经颗粒素。我们的研究结果表明，在一个基于社区的70岁小规模样本中，血浆NfL和脑脊液NfL可能对神经退行性变标志物产生不同的影响。
