针对人类细菌病原体的疫苗开发的先进策略。
Advanced strategies for development of vaccines against human bacterial pathogens.
机构信息
School of Life Sciences, Jawaharlal Nehru University, Aruna Asaf Ali Marg, New Delhi, 110067, India.
Department of Vaccinology, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124, Braunschweig, Germany.
出版信息
World J Microbiol Biotechnol. 2021 Mar 22;37(4):67. doi: 10.1007/s11274-021-03021-6.
Abstract
Infectious diseases are one of the main grounds of death and disabilities in human beings globally. Lack of effective treatment and immunization for many deadly infectious diseases and emerging drug resistance in pathogens underlines the need to either develop new vaccines or sufficiently improve the effectiveness of currently available drugs and vaccines. In this review, we discuss the application of advanced tools like bioinformatics, genomics, proteomics and associated techniques for a rational vaccine design.
摘要
传染病是全球人类死亡和残疾的主要原因之一。许多致命传染病缺乏有效治疗和免疫手段，病原体不断出现耐药性，这凸显了开发新疫苗或充分提高现有药物和疫苗有效性的必要性。在这篇综述中，我们讨论了生物信息学、基因组学、蛋白质组学和相关技术等先进工具在合理疫苗设计中的应用。
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