Sustainable health, Department for Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Division of Psychiatry, Department of Clinical Sciences, Umeå University, Umeå, Sweden.
J Alzheimers Dis. 2021;81(1):83-85. doi: 10.3233/JAD-201538.
Exposure to fine particulate air pollution (PM2.5) is emerging as a risk factor for Alzheimer's disease (AD), but existing studies are still limited and heterogeneous. We have previously studied the association between dementia (AD and vascular dementia) and PM2.5 stemming from vehicle exhaust and wood-smoke in the Betula cohort in Northern Sweden. The aim of this commentary is to estimate the association between total PM2.5 and dementia in the Betula cohort, which is more relevant to include in future meta-estimates than the source-specific estimates. The hazard ratio for incident dementia associated with a 1μg/m3 increase in local PM2.5 was 1.38 (95% confidence interval: 0.99 -1.92). The interpretation of our results is that they indicate an association between local contrasts in concentration of PM2.5 at the residential address and incidence of dementia in a low-level setting.
暴露于细颗粒物空气污染（PM2.5）正成为阿尔茨海默病（AD）的一个风险因素，但现有研究仍然有限且存在异质性。我们之前曾研究过来自瑞典北部白桦队列中车辆尾气和木柴烟雾的 PM2.5 与痴呆（AD 和血管性痴呆）之间的关系。本评论的目的是估算白桦队列中总 PM2.5 与痴呆之间的关联，与源特异性估计相比，这更能纳入未来的荟萃估计。与当地 PM2.5 增加 1μg/m3 相关的痴呆发病风险比为 1.38（95%置信区间：0.99-1.92）。我们的研究结果表明，它们表明在低水平环境中，居住地址处 PM2.5 浓度的局部差异与痴呆的发病率之间存在关联。
