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一名实体器官移植受者中与SARS-CoV-2相关的儿童多系统炎症综合征。

Multisystem inflammatory syndrome in children associated with SARS-CoV-2 in a solid organ transplant recipient.

作者信息

Petters Leanne M, Vogel Tiphanie P, Munoz Flor M, Hernandez Jose A, Koohmaraie Sarah, Nowicki Michael J, Zumbro Caleb E, Mysore Krupa R

机构信息

Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Texas Children's Hospital, Houston, Texas.

出版信息

Am J Transplant. 2021 Jul;21(7):2596-2599. doi: 10.1111/ajt.16572. Epub 2021 Apr 2.

Abstract

We present the case of a 3-year-old female liver transplant recipient with a history of Caroli disease who presented with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) test and was ultimately diagnosed with multisystem inflammatory syndrome in children (MIS-C) complicated by portal vein thrombosis. To the best of our knowledge, this is the first case report of MIS-C in a pediatric solid organ transplant (SOT) recipient. Based on our patient, MIS-C could be a potential complication of Coronavirus disease 2019 (COVID-19) in SOT recipients and may have a negative outcome on transplant graft function.

摘要

我们报告了一名3岁女性肝移植受者的病例,该患者有卡罗里病病史,严重急性呼吸综合征冠状病毒2(SARS-CoV-2)逆转录聚合酶链反应(RT-PCR)检测呈阳性,最终被诊断为儿童多系统炎症综合征(MIS-C)并伴有门静脉血栓形成。据我们所知,这是首例关于儿科实体器官移植(SOT)受者发生MIS-C的病例报告。基于我们的患者情况,MIS-C可能是2019冠状病毒病(COVID-19)在SOT受者中的潜在并发症,并且可能对移植移植物功能产生负面结果。

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