Yates Thomas, Zaccardi Francesco, Islam Nazrul, Razieh Cameron, Gillies Clare L, Lawson Claire A, Chudasama Yogini, Rowlands Alex, Davies Melanie J, Docherty Annemarie B, Openshaw Peter J M, Baillie J Kenneth, Semple Malcolm G, Khunti Kamlesh
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC), University Hospitals of Leicester NHS Trust and University of Leicester, Leicester, UK.
Obesity (Silver Spring). 2021 Jul;29(7):1223-1230. doi: 10.1002/oby.23178. Epub 2021 May 14.
The aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups.
Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases.
Of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity.
Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.
本研究旨在调查肥胖与不同种族群体中2019冠状病毒病（COVID-19）住院结局之间的关联。
纳入2020年2月6日至10月12日期间通过国际严重急性呼吸和新发感染联盟（ISARIC）制定的英国临床特征协议（CCP-UK）在英国因COVID-19入院的患者。种族分为白人、南亚人、黑人及其他少数族裔群体。结局指标为重症监护入院、机械通气及院内死亡，并对年龄、性别和慢性病进行了校正。
纳入的参与者中，54254人（年龄=76岁；45.0%为女性）为白人，3728人（57岁；41.1%为女性）为南亚人，2523人（58岁；44.9%为女性）为黑人，5427人（61岁；40.8%为女性）为其他种族。肥胖与所有种族群体的所有结局均相关，在黑人种族中关联最强。按种族和肥胖状态分层时，肥胖的黑人种族进入重症监护、机械通气和死亡的比值比分别为3.91（3.13 - 4.88）、5.03（3.94 - 6.63）和1.93（1.49 - 2.51），而无肥胖的白人种族则分别为上述比值。
肥胖与所有种族群体中COVID-19住院结局风险升高相关，在黑人种族中关联最强。
