Department of Chronic Condition Diseases and Sexually Transmitted Infections, Health Surveillance Secretariat, Ministry of Health, Brazil, SRTVN Quadra 701, Lote D, Edifício PO700 - 5° andar, Brasília, Distrito Federal, 70719-040, Brazil.
Public Health Department, University of Brasilia, Brasilia, Brazil.
BMC Public Health. 2021 Mar 23;21(1):572. doi: 10.1186/s12889-021-10596-0.
The Zika virus outbreak has triggered a set of local and global actions for a rapid, effective, and timely public health response. A World Health Organization (WHO) initiative, supported by the Department of Chronic Condition Diseases and Sexually Transmitted Infections (DCCI) of the Health Surveillance Secretariat (SVS), Brazil Ministry of Health (MoH) and other public health funders, resulted in the start of the "Study on the persistence of Zika virus in body fluids of patients with ZIKV infection in Brazil - ZIKABRA study". The ZIKABRA study was designed to increase understanding of how long ZIKV persists in bodily fluids and informing best measures to prevent its transmission. Data collection began in July 2017 and the last follow up visit occurred in 06/26/2020.
A framework for the ZIKABRA Cooperation initiative is provided through a description and analysis of the mechanisms, strategies and the ethos that have guided the models of international governance and technical cooperation in health for scientific exchange in the context of a public health emergency. Among the methodological strategies, we included a review of the legal documents that supported the ZIKABRA Cooperation; weekly documents produced in the meetings and working sessions; technical reports; memorandum of understanding and the research protocol.
We highlight the importance of working in cooperation between different institutional actors to achieve more significant results than that obtained by each group working in isolation. In addition, we point out the advantages of training activities, ongoing supervision, the construction of local installed research capacity, training academic and non-academic human resources, improvement of laboratory equipment, knowledge transfer and the availability of the ZIKABRA study protocol for development of similar studies, favoring the collective construction of knowledge to provide public health emergency responses. Strategy harmonization; human resources and health services; timing and recruiting particularities and processing institutional clearance in the different sites can be mentioned as challenges in this type of initiative.
寨卡病毒疫情引发了一系列地方和全球行动，以快速、有效和及时地应对公共卫生。世界卫生组织（世卫组织）的一项倡议得到了巴西卫生部慢性病和性传播感染司（DCCI）、健康监测秘书处（SVS）以及其他公共卫生资助者的支持，该倡议启动了“巴西寨卡病毒感染患者体液中寨卡病毒持续存在研究 - ZIKABRA 研究”。ZIKABRA 研究旨在增进对寨卡病毒在体液中持续存在时间的了解，并为预防其传播提供最佳措施。数据收集于 2017 年 7 月开始，最后一次随访发生在 2020 年 6 月 26 日。
通过描述和分析在公共卫生紧急情况下指导国际治理和卫生技术合作模式的机制、战略和精神，为 ZIKABRA 合作倡议提供了一个框架。在方法策略中，我们包括了支持 ZIKABRA 合作的法律文件的审查；会议和工作会议每周制作的文件；技术报告；谅解备忘录和研究方案。
我们强调了不同机构参与者之间合作的重要性，以取得比每个团体孤立工作更大的成果。此外，我们指出了培训活动、持续监督、建立当地已安装的研究能力、培训学术和非学术人力资源、改进实验室设备、知识转移和 ZIKABRA 研究方案的可用性的优势，有利于集体建设知识，为公共卫生应急反应提供支持。战略协调；人力资源和卫生服务；时间安排和征聘的特殊性以及不同地点的机构审批程序可以被视为此类倡议的挑战。
