Department of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.
Int J Oncol. 2021 May;58(5). doi: 10.3892/ijo.2021.5200. Epub 2021 Mar 24.
MicroRNAs (miRNAs/miRs) are a class of small non‑coding RNAs that maintain the precise balance of various physiological processes through regulating the function of target mRNAs. Dysregulation of miRNAs is closely associated with various types of human cancer. miR‑222‑3p is considered a canonical factor affecting the expression and signal transduction of multiple genes involved in tumor occurrence and progression. miR‑222‑3p in human biofluids, such as urine and plasma, may be a potential biomarker for the early diagnosis of tumors. In addition, miR‑222‑3p acts as a prognostic factor for the survival of patients with cancer. The present review first summarizes and discusses the role of miR‑222‑3p as a biomarker for diverse types of cancers, and then focuses on its essential roles in tumorigenesis, progression, metastasis and chemoresistance. Finally, the current understanding of the regulatory mechanisms of miR‑222‑3p at the molecular level are summarized. Overall, the current evidence highlights the crucial role of miR‑222‑3p in cancer diagnosis, prognosis and treatment.
微小 RNA（miRNA/miRs）是一类小型非编码 RNA，通过调节靶 mRNA 的功能来维持各种生理过程的精确平衡。miRNA 的失调与多种人类癌症密切相关。miR-222-3p 被认为是影响肿瘤发生和发展过程中涉及的多种基因表达和信号转导的典型因素。人生物体液（如尿液和血浆）中的 miR-222-3p 可能是肿瘤早期诊断的潜在生物标志物。此外，miR-222-3p 作为癌症患者生存的预后因素。本综述首先总结和讨论了 miR-222-3p 作为多种癌症生物标志物的作用，然后重点讨论了其在肿瘤发生、进展、转移和化疗耐药性中的重要作用。最后，总结了 miR-222-3p 在分子水平上的调控机制的现有认识。总的来说，目前的证据强调了 miR-222-3p 在癌症诊断、预后和治疗中的关键作用。
