Departamento de Investigación en Toxicología y Medicina Ambiental, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX, México.
Cátedras CONACyT, CDMX, México.
PLoS One. 2021 Mar 25;16(3):e0249057. doi: 10.1371/journal.pone.0249057. eCollection 2021.
Osteopontin (OPN) is a protein involved in inflammatory illnesses such as fibrosis and cancer; its overexpression in cardiovascular diseases promotes the biomineralization of blood vessels and other soft tissues. Moreover, there is an active component of oxidative stress related with those diseases. The present study relates serum OPN levels with nutritional condition and oxidative stress in a group of adolescents. Anthropometric measurements were performed, and fasting blood samples were analyzed to determine OPN concentrations, blood chemistry parameters (glucose, triglycerides, total cholesterol, urea, uric acid, and creatinine) and oxidative stress biomarkers (Paraoxonase-1, Glutathione S-Transferase, Catalase, NAD(P)H Quinone Oxidoreductase, free carbonyl groups and malondialdehyde). Adolescents were categorized according to body mass index (BMI) and metabolic syndrome (MetS) criteria. We found increased OPN serum concentrations in overweight and obese adolescents, as well as in adolescents with MetS. Rises in OPN correlated with arm circumference and biomarkers of lipid peroxidation; with regard to serum glucose there was a trend to positive correlation. Our results suggest that serum OPN is associated to nutritional status and could be considered as an early biomarker of low-grade inflammation and probably the early biomineralization of soft tissues in adolescence.
骨桥蛋白（OPN）是一种参与炎症性疾病（如纤维化和癌症）的蛋白质；它在心血管疾病中的过度表达促进了血管和其他软组织的生物矿化。此外，与这些疾病相关的还有一个活跃的氧化应激成分。本研究将一组青少年的血清 OPN 水平与营养状况和氧化应激联系起来。进行了人体测量学测量，并分析了空腹血样以确定 OPN 浓度、血液化学参数（葡萄糖、甘油三酯、总胆固醇、尿素、尿酸和肌酐）和氧化应激生物标志物（对氧磷酶 1、谷胱甘肽 S-转移酶、过氧化氢酶、NAD(P)H 醌氧化还原酶、游离羰基和丙二醛）。根据体重指数（BMI）和代谢综合征（MetS）标准对青少年进行分类。我们发现超重和肥胖青少年以及患有 MetS 的青少年的血清 OPN 浓度升高。OPN 的升高与臂围和脂质过氧化生物标志物相关；关于血清葡萄糖，存在正相关趋势。我们的结果表明，血清 OPN 与营养状况有关，可被视为低度炎症的早期生物标志物，可能是青少年软组织早期生物矿化的标志物。
