Clark Hannah, Rana Rezwanul, Gow Jeff, Pearson Melissa, van der Touw Tom, Smart Neil
School of Science and Technology, University of New England, Armidale, Australia.
School of Commerce, University of Southern Queensland, Toowoomba, Australia.
Heart Fail Rev. 2022 Mar;27(2):559-572. doi: 10.1007/s10741-021-10097-7. Epub 2021 Mar 25.
Heart failure with preserved ejection fraction (HFpEF) is problematic to treat, with guidelines for HFpEF management concentrated on treating prevalent comorbidities. The aim of this study is to conduct a systematic review of the economic burden of hospitalisation for HFpEF. We conducted a systematic literature search from 2001, when HFpEF was first identified as an isolated diagnosis, up to July 1, 2020. Databases searched include PubMed, Medline, EMBASE, EBSCO, National Health Service Economic Evaluation and the National Bureau of Economic Research. The primary outcome measure was hospitalisation costs related to HFpEF. A comprehensive search of the literature produced a total of 243 possible studies. A total of nine studies, six from the U.S., met inclusion criteria and were included in this review. All results are presented in United States Dollars (US$) for the financial year 2019. Costs of index (the first) hospitalisation ranged from mean US$8340 up to US$11,366 per admission and increased up to US$31,493 for those with comorbidities. Two studies reported 1-year costs, and these were US$27,174 and US$26,343, respectively. Hospitalisation accounts for approximately 80% of total costs of HFpEF treatment. The results of this systematic review reveal that published costs of HFpEF hospitalisation are limited to nine studies from a comprehensive database search. The costs of an initial HF hospitalisation are significant, and these costs increase when a person with HFpEF presents with comorbidities or other complications.
射血分数保留的心力衰竭（HFpEF）治疗起来颇具问题，HFpEF管理指南主要集中于治疗常见的合并症。本研究的目的是对HFpEF住院的经济负担进行系统评价。我们从2001年（HFpEF首次被确定为一种独立诊断时）至2020年7月1日进行了系统的文献检索。检索的数据库包括PubMed、Medline、EMBASE、EBSCO、英国国家医疗服务体系经济评估数据库和美国国家经济研究局数据库。主要结局指标是与HFpEF相关的住院费用。对文献进行全面检索共得到243项可能的研究。共有9项研究符合纳入标准并被纳入本评价，其中6项来自美国。所有结果均以2019财年的美元表示。首次住院的费用平均每次入院为8340美元至11366美元，合并症患者的费用增至31493美元。两项研究报告了1年的费用，分别为27174美元和26343美元。住院费用约占HFpEF治疗总费用的80%。本系统评价的结果显示，从全面的数据库检索中仅得到9项关于HFpEF住院费用的已发表研究。HF首次住院的费用很高，当HFpEF患者出现合并症或其他并发症时，这些费用会增加。
