Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan; Department of Frontier Science for Advanced Environment, Graduate School of Environmental Studies, Tohoku University, Miyagi, Japan.
Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan.
J Hosp Infect. 2021 Jun;112:37-41. doi: 10.1016/j.jhin.2021.03.014. Epub 2021 Mar 22.
This study investigated the potential of olanexidine gluconate as environmental disinfectant against enveloped viruses in the suspension test and three non-porous surface tests. In the suspension test, olanexidine gluconate showed immediate virucidal activity. In addition, non-porous surface tests demonstrated that, although the immediate effect of aqueous formulations was weak, the final virucidal efficacy outcompeted that of ethanol for disinfection. Furthermore, the effectiveness of olanexidine gluconate persisted even after drying on environmental surfaces. This study demonstrated the potential usage of olanexidine gluconate formulations as an environmental disinfectant in the infection control of enveloped viruses.
本研究考察了葡萄糖酸奥替尼啶作为环境消毒剂对悬浮试验和三种非多孔表面试验中包膜病毒的潜力。在悬浮试验中，葡萄糖酸奥替尼啶表现出即刻的病毒杀灭活性。此外，非多孔表面试验表明，尽管水制剂的即时效果较弱，但最终的病毒杀灭效果优于乙醇的消毒效果。此外，即使在环境表面干燥后，葡萄糖酸奥替尼啶的有效性仍然存在。本研究表明，葡萄糖酸奥替尼啶制剂在包膜病毒的感染控制中具有作为环境消毒剂的潜在用途。
