Is a Prognostic-Related Biomarker and Correlated With Immune Infiltrates in Hepatocellular Carcinoma.

participates in the regulation of cell apoptosis and proliferation by regulating the binding of centromere and spindle microtubules to achieve the correct separation of chromosomes. Previous reports have suggested that may play a role in various human cancers. However, the mechanism and function of in the development of Hepatocellular carcinoma (HCC) remains uncertain. This study investigated the prognostic potential of and its relation with immune cell infiltration in HCC. expression in tumor cells was examined using the TIMER and Oncomine databases, and its prognostic potential was assessed the Kaplan-Meier plotter and GEPIA databases. The relationships between and tumor immune infiltration were analyzed using TIMER. The relationships between and biomarkers of tumor immune infiltration were analyzed using TIMER and GEPIA. Here we revealed that expression increased in tumor tissues containing HCC, and this correlated with poor relapse-free survival, disease-specific survival, progression-free survival, and overall survival in patients with HCC regardless of grades, genders, races, drinking behaviors and other clinical factors. Additionally, high expression of was positively correlated with differential immune cell infiltration and various immune biomarkers. Our work demonstrated that could be a potential prognostic biomarker and could be related to tumor immune cell infiltration in HCC.