Grundy S M, Florentin L, Nix D, Whelan M F
Sam Rayburn Memorial Veterans Administration Medical Center, Bonham, TX.
Am J Clin Nutr. 1988 Jun;47(6):965-9. doi: 10.1093/ajcn/47.6.965.
To compare monounsaturated fatty acids and carbohydrates for actions on lipid and lipoprotein levels from solid-food diets, 10 men were studied on three diets. One diet was high in saturated fatty acids and very high in cholesterol (High Sat + Chol), a second was high in monounsaturates but low in cholesterol (High Mono), and a third was low in fat, high in carbohydrates, and low in cholesterol (Low Fat). All diets were consumed for 6 wk. Compared with the High Sat + Chol diet, the High Mono and Low Fat diets significantly and similarly reduced plasma cholesterol and LDL cholesterol. In contrast, the Low Fat diet significantly lowered HDL cholesterol whereas the High Mono diet did not. Therefore, a solid-food diet rich in monounsaturated fatty acids is equivalent to a low-fat, high-carbohydrate diet for cholesterol lowering but does not reduce the HDL-cholesterol level.
为比较单不饱和脂肪酸和碳水化合物对固体食物饮食中脂质和脂蛋白水平的影响，对10名男性进行了三种饮食的研究。一种饮食富含饱和脂肪酸且胆固醇含量极高（高饱和脂肪酸+胆固醇），第二种饮食富含单不饱和脂肪酸但胆固醇含量低（高单不饱和脂肪酸），第三种饮食脂肪含量低、碳水化合物含量高且胆固醇含量低（低脂肪）。所有饮食均持续食用6周。与高饱和脂肪酸+胆固醇饮食相比，高单不饱和脂肪酸和低脂肪饮食显著且相似地降低了血浆胆固醇和低密度脂蛋白胆固醇。相比之下，低脂肪饮食显著降低了高密度脂蛋白胆固醇，而高单不饱和脂肪酸饮食则没有。因此，富含单不饱和脂肪酸的固体食物饮食在降低胆固醇方面等同于低脂肪、高碳水化合物饮食，但不会降低高密度脂蛋白胆固醇水平。
