Suppr超能文献

Drugging multiple same-allele driver mutations in cancer.

作者信息

Nussinov Ruth, Zhang Mingzhen, Maloney Ryan, Jang Hyunbum

机构信息

Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick U.S.A.

Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University Israel.

出版信息

Expert Opin Drug Discov. 2021 Aug;16(8):823-828. doi: 10.1080/17460441.2021.1905628. Epub 2021 Mar 26.

Abstract
摘要

相似文献

1
Drugging multiple same-allele driver mutations in cancer.针对癌症中多个相同等位基因驱动突变进行药物治疗。
Expert Opin Drug Discov. 2021 Aug;16(8):823-828. doi: 10.1080/17460441.2021.1905628. Epub 2021 Mar 26.
5
Drugging K-Ras through covalent inhibitors: Mission possible?通过共价抑制剂对 K-Ras 进行药物干预:可能实现吗?
Pharmacol Ther. 2019 Oct;202:1-17. doi: 10.1016/j.pharmthera.2019.06.007. Epub 2019 Jun 22.
6
PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective.PI3K 驱动突变:一种基于生物物理膜的视角。
Cancer Res. 2021 Jan 15;81(2):237-247. doi: 10.1158/0008-5472.CAN-20-0911. Epub 2020 Oct 12.

引用本文的文献

2
Protein conformational ensembles in function: roles and mechanisms.发挥功能的蛋白质构象集合:作用与机制
RSC Chem Biol. 2023 Sep 5;4(11):850-864. doi: 10.1039/d3cb00114h. eCollection 2023 Nov 1.
3
Strategy toward Kinase-Selective Drug Discovery.激酶选择性药物发现策略。
J Chem Theory Comput. 2023 Mar 14;19(5):1615-1628. doi: 10.1021/acs.jctc.2c01171. Epub 2023 Feb 23.
5
A New View of Activating Mutations in Cancer.癌症激活突变的新观点。
Cancer Res. 2022 Nov 15;82(22):4114-4123. doi: 10.1158/0008-5472.CAN-22-2125.
6
Neurodevelopmental disorders, immunity, and cancer are connected.神经发育障碍、免疫和癌症之间存在关联。
iScience. 2022 May 30;25(6):104492. doi: 10.1016/j.isci.2022.104492. eCollection 2022 Jun 17.
7
Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs.变构作用:变构致癌驱动因子和创新变构药物。
J Mol Biol. 2022 Sep 15;434(17):167569. doi: 10.1016/j.jmb.2022.167569. Epub 2022 Apr 1.
8
Allostery, and how to define and measure signal transduction.变构作用以及如何定义和测量信号转导。
Biophys Chem. 2022 Apr;283:106766. doi: 10.1016/j.bpc.2022.106766. Epub 2022 Jan 29.
9
Anticancer drug resistance: An update and perspective.抗癌药物耐药性:更新与展望。
Drug Resist Updat. 2021 Dec;59:100796. doi: 10.1016/j.drup.2021.100796. Epub 2021 Dec 16.

本文引用的文献

1
Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition.磷酸化和 PI3Kα 及 PTEN 自动抑制中的驱动突变。
Mol Cancer Res. 2021 Apr;19(4):543-548. doi: 10.1158/1541-7786.MCR-20-0818. Epub 2020 Dec 7.
3
PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective.PI3K 驱动突变:一种基于生物物理膜的视角。
Cancer Res. 2021 Jan 15;81(2):237-247. doi: 10.1158/0008-5472.CAN-20-0911. Epub 2020 Oct 12.
4
PI3K inhibitors: review and new strategies.PI3K抑制剂:综述与新策略
Chem Sci. 2020 May 19;11(23):5855-5865. doi: 10.1039/d0sc01676d. eCollection 2020 Jun 21.
5
A compendium of mutational cancer driver genes.癌症驱动基因突变综合分析
Nat Rev Cancer. 2020 Oct;20(10):555-572. doi: 10.1038/s41568-020-0290-x. Epub 2020 Aug 10.
6
7
Phase and context shape the function of composite oncogenic mutations.相和语境决定了复合致癌突变的功能。
Nature. 2020 Jun;582(7810):100-103. doi: 10.1038/s41586-020-2315-8. Epub 2020 May 27.
9
Are Parallel Proliferation Pathways Redundant?平行增殖途径是多余的吗?
Trends Biochem Sci. 2020 Jul;45(7):554-563. doi: 10.1016/j.tibs.2020.03.013. Epub 2020 Apr 25.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验