Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Sci Total Environ. 2021 Jun 10;772:145475. doi: 10.1016/j.scitotenv.2021.145475. Epub 2021 Jan 30.
Electronic cigarettes (E-cigarette) are an alternative for traditional cigarette smokers to quit smoking. Based on the current understanding, electronic cigarettes have rapidly become popular among existing smokers and former non-smokers. However, increasing research at different levels reveals that e-cigarettes are unsafe. This review provides an overview of the toxicology of e-cigarettes based on existing in vivo and in vitro studies and compares their toxicity with that of traditional cigarettes. Moreover, we describe the associated toxicity components in e-cigarettes, as well as the potential mechanism by which e-cigarettes exert toxic effects. As is known to all, the nicotine in traditional cigarettes and e-cigarettes has certain toxicity. Besides, a few studies have shown that propylene glycol and vegetable glycerin mixture and flavoring agents in e-cigarettes also are the key components causing adverse effects in animals or cells. There is insufficient scientific evidence on the toxicity of e-cigarettes due to the lack of standardized research methods, prompting the need to conduct a comprehensive toxicity assessment of e-cigarette toxicity to elucidate the safety issues of e-cigarettes. Eventually, a basis for decision-making on whether people use e-cigarettes will be obtained.
电子烟（E-cigarette）是传统香烟吸烟者戒烟的一种替代选择。根据目前的了解，电子烟在现有的吸烟者和以前的非吸烟者中迅速流行起来。然而，不同层次的研究不断增加，揭示了电子烟并不安全。本综述根据现有的体内和体外研究，概述了电子烟的毒理学，并将其毒性与传统香烟进行了比较。此外，我们还描述了电子烟中与毒性相关的成分，以及电子烟发挥毒性作用的潜在机制。众所周知，传统香烟和电子烟中的尼古丁具有一定的毒性。此外，一些研究表明，电子烟中的丙二醇和植物甘油混合物以及调味剂也是在动物或细胞中引起不良反应的关键成分。由于缺乏标准化的研究方法，电子烟的毒性缺乏足够的科学证据，这促使我们需要对电子烟的毒性进行全面的毒性评估，以阐明电子烟的安全问题。最终，将为是否使用电子烟做出决策提供依据。
