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足部溃疡为皮肤利什曼病的非典型表现。

Plantar ulcer as an atypical manifestation of cutaneous leishmaniasis.

机构信息

Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Escola Bahiana de Medicina, Salvador, BA, Brazil.

出版信息

An Bras Dermatol. 2021 May-Jun;96(3):352-354. doi: 10.1016/j.abd.2020.06.015. Epub 2021 Mar 15.

DOI:10.1016/j.abd.2020.06.015
PMID:33775479
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8178547/
Abstract

Cutaneous leishmaniasis is characterized by ulcers with raised edges and a granular bottom, mainly on the lower limbs. This is a case report of a male patient with an ulcer on the left plantar region. The diagnosis was confirmed by positive PCR for L. braziliensis and the presence of amastigotes of Leishmania sp. in the histopathological examination. After treatment with Glucantime, the patient showed full healing of the ulcer. The unusual location of the ulceration calls attention to atypical presentations of leishmaniasis, and the importance of histopathological examination and PCR, leading to the appropriate diagnosis and treatment.

摘要

皮肤利什曼病的特征是边缘隆起、底部呈颗粒状的溃疡,主要发生在下肢。这是一例左足底区域出现溃疡的男性患者。通过对 L. braziliensis 的 PCR 检测呈阳性和组织病理学检查中存在利什曼原虫的无鞭毛体,确诊为该病。经葡聚糖胺治疗后,患者的溃疡完全愈合。溃疡的不寻常位置提示利什曼病的非典型表现,组织病理学检查和 PCR 的重要性,从而进行了适当的诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d0f/8178547/7bbd40159dce/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d0f/8178547/e51274226961/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d0f/8178547/7bbd40159dce/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d0f/8178547/e51274226961/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d0f/8178547/7bbd40159dce/gr2.jpg

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本文引用的文献

1
Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects.播散性利什曼病:临床、致病及治疗方面
An Bras Dermatol. 2019 Jan-Feb;94(1):9-16. doi: 10.1590/abd1806-4841.20198775.
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Leprosy: Trophic Skin Ulcers.麻风病:营养性皮肤溃疡
Skinmed. 2017 Feb 1;15(1):45-51. eCollection 2017.
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Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects.在巴西利什曼原虫流行地区皮肤利什曼病的非典型表现:临床、免疫学和寄生虫学方面
PLoS Negl Trop Dis. 2016 Dec 1;10(12):e0005100. doi: 10.1371/journal.pntd.0005100. eCollection 2016 Dec.
4
Association between an emerging disseminated form of leishmaniasis and Leishmania (Viannia) braziliensis strain polymorphisms.新型播散性利什曼病与利什曼原虫(Viannia)巴西利ensis 株多态性之间的关联。
J Clin Microbiol. 2012 Dec;50(12):4028-34. doi: 10.1128/JCM.02064-12. Epub 2012 Oct 3.
5
Healing rates of plantar ulcers in leprosy and diabetes.麻风病和糖尿病患者足底溃疡的愈合率。
Lepr Rev. 1992 Dec;63(4):365-74. doi: 10.5935/0305-7518.19920044.