Sutherland C M, Mather F J
Tulane University School of Medicine, Department of Surgery, New Orleans, LA 70112.
Ann Surg. 1988 May;207(5):569-80. doi: 10.1097/00000658-198805000-00011.
Long-term survival, the prognostic effects of race, age, tumor size, number of positive nodes, and presence of grave signs (fixation, peau d'orange/edema, dimpling/retraction, satellite nodules, and ulceration) in this distribution of estrogen receptors (ERs) and progesterone receptors (PRs) were studied in 2480 patients (1815 blacks, 665 whites) diagnosed with localized or regional breast cancer at Charity Hospital of Louisiana at New Orleans (CHNO) from 1948 to 1985 and followed up in the CHNO Tumor Registry. Breast cancer-specific survival rates were 57%, 45%, 41%, 39%, 38%, and 35% at 5, 10, 15, 20, 25, and 30 years, respectively. Size of tumor, clinical status of nodes, and degree of fixation were important prognostic clinical factors, and number of nodes was an important pathologic factor with no additional value of the "grave signs." Size and fixation were related. Independent of size, clinical and pathologic status and fixation were related. ER was related to age and PR was related to number of nodes. The excess mortality from breast cancer at later intervals from diagnoses was small compared with mortality from other causes. Some, but not all, clinical findings were important prognostic indicators. ER and PR were related to some variables with unclear meaning.
对1948年至1985年在新奥尔良的路易斯安那慈善医院（CHNO）诊断为局限性或区域性乳腺癌的2480例患者（1815例黑人，665例白人）进行了研究，这些患者的雌激素受体（ERs）和孕激素受体（PRs）呈这种分布情况，研究内容包括长期生存情况，以及种族、年龄、肿瘤大小、阳性淋巴结数量和严重体征（固定、橘皮样变/水肿、酒窝征/回缩、卫星结节和溃疡）的预后影响，这些患者在CHNO肿瘤登记处进行了随访。乳腺癌特异性生存率在5年、10年、15年、20年、25年和30年时分别为57%、45%、41%、39%、38%和35%。肿瘤大小、淋巴结临床状态和固定程度是重要的预后临床因素，淋巴结数量是重要的病理因素，“严重体征”并无额外价值。肿瘤大小与固定有关。与肿瘤大小无关，临床和病理状态与固定有关。ER与年龄有关，PR与淋巴结数量有关。与其他原因导致的死亡率相比，诊断后较晚时间段内乳腺癌导致的额外死亡率较小。一些但并非所有的临床发现都是重要的预后指标。ER和PR与一些意义不明确的变量有关。
