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COVID-19 大流行:哪些 IBD 患者需要进行内镜检查——现在应该对谁进行检查,谁可以等待,以及如何恢复正常。

COVID-19 Pandemic: Which IBD Patients Need to Be Scoped-Who Gets Scoped Now, Who Can Wait, and how to Resume to Normal.

机构信息

aInstitute of Digestive Disease, Department of Medicine and Therapeutics, LKS Institute of Health Science, Chinese University of Hong Kong, Hong Kong.

bMount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

出版信息

J Crohns Colitis. 2020 Oct 21;14(14 Suppl 3):S791-S797. doi: 10.1093/ecco-jcc/jjaa128.

Abstract

Endoscopy is an essential component in the management of inflammatory bowel disease [IBD]. There is a risk of SARS-CoV-2 transmission during endoscopic procedures. The International Organization for the study of IBD [IOIBD] has developed 11 position statements, based on an online survey, that focus on how to prioritise endoscopies in IBD patients during the COVID-19 pandemic, alternative modes for disease monitoring, and ways to triage the high number of postponed endoscopies after the pandemic. We propose to pre-screen patients for suspected or confirmed COVID-19 and test for SARS-CoV-2 before endoscopy if available. High priority endoscopies during pandemic include acute gastrointestinal bleed, acute severe ulcerative colitis, new IBD diagnosis, cholangitis in primary sclerosing cholangitis, and partial bowel obstruction. Alternative modes of monitoring using clinical symptoms, serum inflammatory markers, and faecal calprotectin should be considered during the pandemic. Prioritising access to endoscopy in the post-pandemic period should be guided by control of COVID-19 in the local community and availability of manpower and personal protective equipment. Endoscopy should be considered within 3 months after the pandemic for patients with a past history of dysplasia and endoscopic resection for dysplastic lesion. Endoscopy should be considered 3-6 months after the pandemic for assessment of postoperative recurrence or new biologic initiation. Endoscopy can be postponed until after 6 months of pandemic for routine IBD surveillance and assessment of mucosal healing.

摘要

内镜检查是炎症性肠病(IBD)管理的重要组成部分。在进行内镜检查时存在 SARS-CoV-2 传播的风险。国际 IBD 研究组织(IOIBD)基于在线调查制定了 11 项立场声明,重点关注如何在 COVID-19 大流行期间为 IBD 患者优先安排内镜检查、疾病监测的替代模式以及在大流行后对大量推迟的内镜检查进行分诊的方法。我们建议对疑似或确诊 COVID-19 的患者进行预筛查,并在可行的情况下在进行内镜检查前检测 SARS-CoV-2。大流行期间的高优先级内镜检查包括急性胃肠道出血、急性重度溃疡性结肠炎、新的 IBD 诊断、原发性硬化性胆管炎中的胆管炎以及部分肠梗阻。在大流行期间,应考虑使用临床症状、血清炎症标志物和粪便钙卫蛋白等替代监测模式。在大流行后的内镜检查准入应根据当地社区 COVID-19 的控制情况以及人力和个人防护设备的可用性来指导。对于有既往异型增生病史和内镜切除异型增生病变的患者,应在大流行后 3 个月内考虑进行内镜检查。对于术后复发或开始新的生物治疗的患者,应在大流行后 3-6 个月内考虑进行内镜检查。对于常规 IBD 监测和评估黏膜愈合,可以将内镜检查推迟到大流行后 6 个月。

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