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Editorial: The Role of Ceramides in Diabetes and Cardiovascular Disease.

作者信息

Summers Scott A

机构信息

Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States.

出版信息

Front Endocrinol (Lausanne). 2021 Mar 12;12:667885. doi: 10.3389/fendo.2021.667885. eCollection 2021.

DOI:10.3389/fendo.2021.667885
PMID:33776946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7994593/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ba/7994593/3e819afff2b1/fendo-12-667885-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ba/7994593/3e819afff2b1/fendo-12-667885-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ba/7994593/3e819afff2b1/fendo-12-667885-g001.jpg

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本文引用的文献

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Structural insights into adiponectin receptors suggest ceramidase activity.脂联素受体的结构见解提示神经酰胺酶活性。
Nature. 2017 Apr 6;544(7648):120-123. doi: 10.1038/nature21714. Epub 2017 Mar 22.
2
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.受体介导的神经酰胺酶活性的激活启动了脂联素的多效作用。
Nat Med. 2011 Jan;17(1):55-63. doi: 10.1038/nm.2277. Epub 2010 Dec 26.
3
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.从头鞘脂生物合成：一条必要但危险的途径。
补充ω-3可减轻阿霉素诱导的心脏毒性，但与神经酰胺途径无关。
Food Sci Nutr. 2024 Sep 29;12(11):9198-9211. doi: 10.1002/fsn3.4492. eCollection 2024 Nov.
4
Plasma ceramides as biomarkers for microvascular disease and clinical outcomes in diabetes and myocardial infarction.血浆神经酰胺作为糖尿病和心肌梗死微血管疾病及临床结局的生物标志物。
Clin Diabetes Endocrinol. 2024 Sep 17;10(1):32. doi: 10.1186/s40842-024-00186-5.
5
Ceramides as Emerging Players in Cardiovascular Disease: Focus on Their Pathogenetic Effects and Regulation by Diet.神经酰胺在心血管疾病中的新作用：关注其发病机制及饮食调控。
Adv Nutr. 2024 Jul;15(7):100252. doi: 10.1016/j.advnut.2024.100252. Epub 2024 Jun 12.
6
Effect of an eight-week high-intensity interval training programme on circulating sphingolipid levels in middle-aged adults at elevated cardiometabolic risk (SphingoFIT)-Protocol for a randomised controlled exercise trial.一项为期八周的高强度间歇训练方案对心血管代谢风险升高的中年成年人循环神经鞘脂水平的影响（SphingoFIT）-随机对照运动试验方案。
PLoS One. 2024 May 8;19(5):e0302477. doi: 10.1371/journal.pone.0302477. eCollection 2024.
7
Glucokinase Inactivation Ameliorates Lipid Accumulation and Exerts Favorable Effects on Lipid Metabolism in Hepatocytes.葡萄糖激酶失活可改善肝细胞脂质堆积并对脂代谢发挥有益作用。
Int J Mol Sci. 2023 Feb 21;24(5):4315. doi: 10.3390/ijms24054315.
8
Role of ceramides in diabetic foot ulcers (Review).神经酰胺在糖尿病足溃疡中的作用（综述）。
Int J Mol Med. 2023 Mar;51(3). doi: 10.3892/ijmm.2023.5229. Epub 2023 Feb 17.
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Different Metabolism and Toxicity of TRANS Fatty Acids, Elaidate and Vaccenate Compared to Cis-Oleate in HepG2 Cells.反式脂肪酸、亚油酸和鳕油酸与顺式油酸在 HepG2 细胞中的代谢和毒性差异。
Int J Mol Sci. 2022 Jun 30;23(13):7298. doi: 10.3390/ijms23137298.
J Biol Chem. 2002 Jul 19;277(29):25843-6. doi: 10.1074/jbc.R200009200. Epub 2002 May 13.
4
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.肥胖大鼠非胰岛素依赖型糖尿病发病机制中的β细胞脂毒性：脂肪细胞与β细胞关系受损。
Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10878-82. doi: 10.1073/pnas.91.23.10878.
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Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.肥胖相关性非胰岛素依赖型糖尿病发病机制中的脂毒性。遗传学及临床意义。
Diabetes. 1995 Aug;44(8):863-70. doi: 10.2337/diab.44.8.863.