Department of Molecular Cell Biology, University of California at Berkeley, Berkeley, CA, USA.
Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.
EMBO Rep. 2021 Apr 7;22(4):e51078. doi: 10.15252/embr.202051078. Epub 2021 Mar 28.
Transcription is an elaborate process that is required to establish and maintain the identity of the more than two hundred cell types of a metazoan organism. Strict regulation of gene expression is therefore vital for tissue formation and homeostasis. An accumulating body of work found that ubiquitylation of histones, transcription factors, or RNA polymerase II is crucial for ensuring that transcription occurs at the right time and place during development. Here, we will review principles of ubiquitin-dependent control of gene expression and discuss how breakdown of these regulatory circuits leads to a wide array of human diseases.
转录是一个精细的过程，它需要建立和维持多细胞生物的两百多种细胞类型的特征。因此，基因表达的严格调控对组织形成和内稳态至关重要。越来越多的研究发现，组蛋白、转录因子或 RNA 聚合酶 II 的泛素化对于确保在发育过程中适时适当地进行转录至关重要。在这里，我们将回顾泛素依赖性基因表达调控的原则，并讨论这些调控回路的破坏如何导致广泛的人类疾病。
