Ophthalmology, Flinders University, Adelaide, South Australia, Australia
Ophthalmology, Flinders University, Adelaide, South Australia, Australia.
Br J Ophthalmol. 2022 Jul;106(7):952-956. doi: 10.1136/bjophthalmol-2020-317461. Epub 2021 Mar 29.
BACKGROUND/AIMS: Recent research suggests an association between normal-tension glaucoma (NTG) and dementia. This study investigated whether cognitive impairment is more strongly associated with NTG than high tension glaucoma (HTG) using cognitive screening within an Australiasian Glaucoma Disease Registry.
The authors completed a case-control cross-sectional cognitive screening involving 290 age-matched and sex-matched NTG participants and HTG controls aged ≥65 randomly sampled from the Australian and New Zealand Registry of Advanced Glaucoma. Cognitive screening was performed using the Telephone Version of the Montreal Cognitive Assessment (T-MoCA). The T-MoCA omits points requiring visual interpretation, accounting for confounding factors related to vision loss in visually impaired participants. Cognitive impairment was defined by a T-MoCA score of <11/22. Cognition was compared between NTG and HTG participants using predetermined thresholds and absolute screening scores.
A total of 290 participants completed cognitive assessment. There were no differences in NTG (n=144) and HTG (n=146) cohort demographics or ocular parameters at baseline. Cognitive impairment was more prevalent in the NTG cohort than the HTG cohort (OR=2.2; 95% CI 1.1 to 6.7, p=0.030). Though a linear trend was also observed between lower absolute T-MoCA scores in the NTG cohort when compared with the HTG cohort, this association was not statistically significant (p=0.108).
This study demonstrated an association between NTG status and poor cognition, supporting the hypothesis that there exists a disease association and shared pathoaetiological features between NTG and dementia.
背景/目的：最近的研究表明，正常眼压性青光眼（NTG）与痴呆之间存在关联。本研究通过澳大利亚和新西兰青光眼疾病登记处的认知筛查，调查认知障碍与 NTG 的相关性是否强于高眼压性青光眼（HTG）。
作者对年龄和性别匹配的 290 名 NTG 参与者和随机抽取的年龄≥65 岁的 HTG 对照组进行了病例对照横断面认知筛查，这些参与者均来自澳大利亚和新西兰高级青光眼登记处。认知筛查使用了电话版蒙特利尔认知评估（T-MoCA）。T-MoCA 省略了需要视觉解释的分数，考虑了与视力受损参与者视力丧失相关的混杂因素。认知障碍通过 T-MoCA 得分<11/22 来定义。使用预定的阈值和绝对筛查分数比较了 NTG 和 HTG 参与者之间的认知能力。
共有 290 名参与者完成了认知评估。在基线时，NTG（n=144）和 HTG（n=146）队列的人口统计学特征或眼部参数没有差异。NTG 队列的认知障碍比 HTG 队列更常见（OR=2.2；95%CI 1.1 至 6.7，p=0.030）。尽管还观察到 NTG 队列的绝对 T-MoCA 评分比 HTG 队列低的线性趋势，但这种关联没有统计学意义（p=0.108）。
本研究表明 NTG 状态与认知障碍之间存在关联，支持了 NTG 和痴呆之间存在疾病关联和共同的病理生理特征的假说。
