Chin K P, Govindarajan S, Redeker A G
Department of Medicine, University of Southern California School of Medicine Rancho Los Amigos Hospital, Downey 90242.
Dig Dis Sci. 1988 Jul;33(7):851-6. doi: 10.1007/BF01550975.
Three patients are described with chronic hepatitis B virus infection for three to six years before hepatitis delta virus superinfection occurred. Liver biopsy performed in two patients prior to their delta illness revealed chronic persistent hepatitis and chronic active hepatitis, respectively. Within one to seven months of the acute delta event, all three patients lost their circulating hepatitis B surface antigen. Subsequently, delta antibody also cleared. Clinical well-being and normal transaminases were documented over 10-44 months of follow-up. Although most cases of delta infection in chronic hepatitis B result in severe or progressive disease, a small number of patients may develop clearance of the HBsAg with clearance of both B and delta infections.
本文描述了3例慢性乙型肝炎病毒感染患者，在丁型肝炎病毒重叠感染发生前，已感染3至6年。其中2例患者在丁型肝炎发病前进行了肝活检，分别显示为慢性持续性肝炎和慢性活动性肝炎。在急性丁型肝炎事件发生后的1至7个月内，所有3例患者的循环乙型肝炎表面抗原均消失。随后，丁型抗体也清除了。在10至44个月的随访中，记录到患者临床状况良好，转氨酶正常。虽然慢性乙型肝炎患者发生丁型肝炎感染大多会导致严重或进行性疾病，但少数患者可能会在清除乙型和丁型感染的同时清除乙肝表面抗原。
