Shi Yuzhi, Li Zhenyu, Liu Patricia Yang, Nguyen Binh Thi Thanh, Wu Wenshuai, Zhao Qianbin, Chin Lip Ket, Wei Minggui, Yap Peng Huat, Zhou Xiaohong, Zhao Hongwei, Yu Dan, Tsai Din Ping, Liu Ai Qun
School of Electrical and Electronic Engineering Nanyang Technological University Singapore 639798 Singapore.
National Key Laboratory of Science and Technology on Micro/Nano Fabrication Institute of Microelectronics Peking University Beijing 100871 China.
Adv Photonics Res. 2021 Apr;2(4):2000150. doi: 10.1002/adpr.202000150. Epub 2021 Feb 25.
The current outbreak of the coronavirus disease-19 (COVID-19) pandemic worldwide has caused millions of fatalities and imposed a severe impact on our daily lives. Thus, the global healthcare system urgently calls for rapid, affordable, and reliable detection toolkits. Although the gold-standard nucleic acid amplification tests have been widely accepted and utilized, they are time-consuming and labor-intensive, which exceedingly hinder the mass detection in low-income populations, especially in developing countries. Recently, due to the blooming development of photonics, various optical chips have been developed to detect single viruses with the advantages of fast, label-free, affordable, and point of care deployment. Herein, optical approaches especially in three perspectives, e.g., flow-free optical methods, optofluidics, and surface-modification-assisted approaches, are summarized. The future development of on-chip optical-detection methods in the wave of emerging new ideas in nanophotonics is also briefly discussed.
当前全球范围内爆发的新型冠状病毒肺炎（COVID-19）大流行已导致数百万人死亡，并对我们的日常生活造成了严重影响。因此，全球医疗保健系统迫切需要快速、经济且可靠的检测工具包。尽管金标准核酸扩增检测已被广泛接受和使用，但它们耗时且 labor-intensive，这极大地阻碍了低收入人群，尤其是发展中国家的大规模检测。最近，由于光子学的蓬勃发展，已开发出各种光学芯片来检测单个病毒，具有快速、无标记、经济且可床边检测的优点。在此，总结了光学方法，特别是从三个角度，即无流动光学方法、光流体学和表面修饰辅助方法。还简要讨论了在纳米光子学新思想浪潮中芯片上光学检测方法的未来发展。
