Buchanan Gordon F, Gluckman Bruce J, Kalume Franck K, Lhatoo Samden, Maganti Rama K, Noebels Jeffrey L, Simeone Kristina A, Quigg Mark S, Pavlova Milena K
Department of Neurology and Iowa Neuroscience Institute, 12243University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Department of Engineering Science & Mechanics, 8082Penn State University, University Park, PA, USA.
Epilepsy Curr. 2021 Mar 31;21(3):15357597211004556. doi: 10.1177/15357597211004556.
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Likely pathophysiological mechanisms include seizure-induced cardiac and respiratory dysregulation. A frequently identified feature in SUDEP cases is that they occur at night. This raises the question of a role for sleep state in regulating of SUDEP. An association with sleep has been identified in a number of studies with patients and in animal models. The focus of this section of the Sleep and Epilepsy Workshop was on identifying and understanding the role for sleep and time of day in the pathophysiology of SUDEP.
癫痫猝死（SUDEP）是难治性癫痫患者的主要死因。可能的病理生理机制包括癫痫发作诱发的心脏和呼吸调节异常。SUDEP病例中一个常见的特征是死亡发生在夜间。这就引出了睡眠状态在调节SUDEP中是否起作用的问题。在多项针对患者的研究以及动物模型中，均已发现与睡眠存在关联。睡眠与癫痫研讨会这一部分的重点是确定并理解睡眠和一天中的时间在SUDEP病理生理学中的作用。
