Zhang Weiya, Liu Yuan, Zhang Hong
Agricultural Technology Innovation Center in Mountainous Areas of Hebei Province and National Engineering Research Center for Agriculture in Northern Mountainous Areas, Hebei Agricultural University, No. 289 Lingyusi Street, Lianchi District, Baoding, 071001, Hebei, People's Republic of China.
Institute of Zoology, Chinese Academy of Sciences, Beichen West Road, Chaoyang District, Beijing, 100101, People's Republic of China.
Cell Biosci. 2021 Mar 31;11(1):65. doi: 10.1186/s13578-021-00579-4.
Extracellular matrix (ECM) is a kind of connective tissue in the cell microenvironment, which is of great significance to tissue development. ECM in muscle fiber niche consists of three layers: the epimysium, the perimysium, and the endomysium (basal lamina). These three layers of connective tissue structure can not only maintain the morphology of skeletal muscle, but also play an important role in the physiological functions of muscle cells, such as the transmission of mechanical force, the regeneration of muscle fiber, and the formation of neuromuscular junction. In this paper, detailed discussions are made for the structure and key components of ECM in skeletal muscle tissue, the role of ECM in skeletal muscle development, and the application of ECM in biomedical engineering. This review will provide the reader with a comprehensive overview of ECM, as well as a comprehensive understanding of the structure, physiological function, and application of ECM in skeletal muscle tissue.
细胞外基质（ECM）是细胞微环境中的一种结缔组织，对组织发育具有重要意义。肌纤维生态位中的细胞外基质由三层组成：肌外膜、肌束膜和肌内膜（基膜）。这三层结缔组织结构不仅可以维持骨骼肌的形态，还在肌肉细胞的生理功能中发挥重要作用，如机械力的传递、肌纤维的再生以及神经肌肉接头的形成。本文对骨骼肌组织中细胞外基质的结构和关键成分、细胞外基质在骨骼肌发育中的作用以及细胞外基质在生物医学工程中的应用进行了详细讨论。这篇综述将为读者提供关于细胞外基质的全面概述，以及对细胞外基质在骨骼肌组织中的结构、生理功能和应用的全面理解。
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