Ni Zhexin, Cheng Wen, Ding Jie, Yao Ruipin, Zhang Danying, Zhai Dongxia, Zhou Ling, Yu Chaoqin
Department of Traditional Chinese Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Evid Based Complement Alternat Med. 2021 Mar 15;2021:6671367. doi: 10.1155/2021/6671367. eCollection 2021.
Gut microbiota disorders are closely related to polycystic ovarian syndrome (PCOS). Buzhong Yiqi prescription (BZYQ) has a significant clinical effect on the treatment of patients with obesity exhibiting PCOS and phlegm-dampness syndrome caused by spleen deficiency (SPSD). Hence, this study aimed to explore gut microbiota and fecal metabolite alterations in such patients treated with BZYQ. Fifty eligible patients with obesity manifesting PCOS and SPSD participated and agreed to undergo 3 months of BZYQ treatment. Results showed that BZYQ significantly alleviated the serum dehydroepiandrosterone sulfate ( < 0.001) and testosterone levels ( < 0.001) and markedly changed the gut microbiota structure in these patients. Furthermore, 106 differential fecal metabolites and 14 KEGG enrichment pathways were quantified. The phylum Spirochaetae and the genera , , and were significantly more abundant, but was significantly less abundant after treatment than before treatment. Disorders in the gut microbiota and fecal metabolites of these patients were closely related to hyperandrogenemia and insulin resistance. In conclusion, BZYQ could ameliorate the serum androgen level and had an impact on the gut microbiota and metabolites in patients with obesity manifesting PCOS and SPSD.
肠道微生物群紊乱与多囊卵巢综合征（PCOS）密切相关。补中益气方（BZYQ）对治疗肥胖型PCOS及脾虚痰湿证（SPSD）患者具有显著临床疗效。因此，本研究旨在探讨BZYQ治疗此类患者后肠道微生物群和粪便代谢物的变化。50例符合条件的肥胖型PCOS及SPSD患者参与并同意接受3个月的BZYQ治疗。结果显示，BZYQ显著降低了血清硫酸脱氢表雄酮水平（<0.001）和睾酮水平（<0.001），并显著改变了这些患者的肠道微生物群结构。此外，还定量分析了106种差异粪便代谢物和14条KEGG富集通路。治疗后，螺旋体门以及、和属的丰度显著增加，但的丰度显著低于治疗前。这些患者的肠道微生物群和粪便代谢物紊乱与高雄激素血症和胰岛素抵抗密切相关。总之，BZYQ可改善血清雄激素水平，并对肥胖型PCOS及SPSD患者的肠道微生物群和代谢物产生影响。
