Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 T�bingen, Germany.
Plant Cell. 2021 May 31;33(4):814-831. doi: 10.1093/plcell/koaa002.
Plants and pathogens constantly adapt to each other. As a consequence, many members of the plant immune system, and especially the intracellular nucleotide-binding site leucine-rich repeat receptors, also known as NOD-like receptors (NLRs), are highly diversified, both among family members in the same genome, and between individuals in the same species. While this diversity has long been appreciated, its true extent has remained unknown. With pan-genome and pan-NLRome studies becoming more and more comprehensive, our knowledge of NLR sequence diversity is growing rapidly, and pan-NLRomes provide powerful platforms for assigning function to NLRs. These efforts are an important step toward the goal of comprehensively predicting from sequence alone whether an NLR provides disease resistance, and if so, to which pathogens.
植物和病原体不断地相互适应。因此，植物免疫系统的许多成员，特别是细胞内核苷酸结合位点富含亮氨酸重复受体，也称为 NOD 样受体 (NLRs)，在同一基因组中的家族成员之间以及同一物种的个体之间高度多样化。虽然这种多样性早就被人们所认识，但它的真正程度一直未知。随着泛基因组和泛 NLRome 研究变得越来越全面，我们对 NLR 序列多样性的认识正在迅速增长，而泛 NLRome 为赋予 NLR 功能提供了强大的平台。这些努力是朝着仅从序列全面预测 NLR 是否提供抗病性以及如果提供，针对哪些病原体的目标迈出的重要一步。
