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维甲酸诱导人神经母细胞瘤细胞分化过程中c-myb表达的调控

Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.

作者信息

Thiele C J, Cohen P S, Israel M A

机构信息

Molecular Genetics Section, National Cancer Institute, Bethesda, Maryland 20892.

出版信息

Mol Cell Biol. 1988 Apr;8(4):1677-83. doi: 10.1128/mcb.8.4.1677-1683.1988.

DOI:10.1128/mcb.8.4.1677-1683.1988
PMID:3380093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC363328/
Abstract

We detected expression of the c-myb proto-oncogene, which was initially thought to be expressed in a tissue-specific manner in cells of hematopoietic lineage, in human tissues of neuronal origin. Since the level of c-myb expression declined during fetal development, we studied the regulation of its expression in human neuroblastoma cell lines induced to differentiate by retinoic acid. The expression of c-myb declined during the maturation of neuroblastoma cells, and this change was mediated by a decrease in c-myb transcription.

摘要

我们在源自神经元的人类组织中检测到了c-myb原癌基因的表达，该基因最初被认为仅在造血谱系细胞中以组织特异性方式表达。由于c-myb的表达水平在胎儿发育过程中下降，我们研究了维甲酸诱导分化的人类神经母细胞瘤细胞系中其表达的调控。在神经母细胞瘤细胞成熟过程中，c-myb的表达下降，这种变化是由c-myb转录减少介导的。

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Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.维甲酸诱导人神经母细胞瘤细胞分化过程中c-myb表达的调控
Mol Cell Biol. 1988 Apr;8(4):1677-83. doi: 10.1128/mcb.8.4.1677-1683.1988.
2
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The expression of multiple proto-oncogenes is differentially regulated during retinoic acid induced maturation of human neuroblastoma cell lines.在视黄酸诱导人神经母细胞瘤细胞系成熟的过程中，多种原癌基因的表达受到不同程度的调控。
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引用本文的文献

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MYCN is amplified during S phase, and c‑myb is involved in controlling MYCN expression and amplification in MYCN‑amplified neuroblastoma cell lines.MYCN 在 S 期扩增，c-myb 参与控制 MYCN 表达和 MYCN 扩增神经母细胞瘤细胞系中的扩增。
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Zebrafish blastomere screen identifies retinoic acid suppression of in adenoid cystic carcinoma.斑马鱼胚胎裂球筛选鉴定维甲酸抑制腺样囊性癌中的 。
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c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.

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Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues.逆转录病毒致癌基因细胞同源物的转录本：在鸡组织中的分布
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myb provides an essential function during Drosophila development.myb在果蝇发育过程中发挥着至关重要的作用。
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交感神经母细胞瘤向神经节神经瘤的成熟；分别报告2例存活20年和46年的患者。
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Retinoic acid-induced growth inhibition and morphologic differentiation of human neuroblastoma cells in vitro.维甲酸诱导人神经母细胞瘤细胞在体外的生长抑制及形态分化。
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Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.人类神经母细胞瘤细胞系和一个神经母细胞瘤肿瘤中存在与myc细胞癌基因同源性有限的扩增DNA。
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