Department of Biomedical and Clinical Sciences L. Sacco, Università di Milano, Via G.B. Grassi 74, 20157 Milano, Italy.
INRAE, UNH, Unitéde Nutrition Humaine, Université Clermont Auvergne, 63001 Clermont-Ferrand, France.
Nutrients. 2021 Mar 24;13(4):1049. doi: 10.3390/nu13041049.
Magnesium (Mg) is essential to skeletal muscle where it plays a key role in myofiber relaxation. Although the importance of Mg in the mature skeletal muscle is well established, little is known about the role of Mg in myogenesis. We studied the effects of low and high extracellular Mg in C2C12 myogenic differentiation. Non-physiological Mg concentrations induce oxidative stress in myoblasts. The increase of reactive oxygen species, which occurs during the early phase of the differentiation process, inhibits myoblast membrane fusion, thus impairing myogenesis. Therefore, correct Mg homeostasis, also maintained through a correct dietary intake, is essential to assure the regenerative capacity of skeletal muscle fibers.
镁（Mg）对骨骼肌至关重要，在肌纤维松弛中发挥关键作用。尽管 Mg 在成熟骨骼肌中的重要性已得到充分证实，但对于 Mg 在成肌发生中的作用知之甚少。我们研究了低和高细胞外 Mg 对 C2C12 成肌分化的影响。非生理浓度的 Mg 会在成肌细胞中诱导氧化应激。在分化过程的早期阶段发生的活性氧增加，抑制成肌细胞的膜融合，从而损害成肌发生。因此，正确的镁动态平衡（也通过正确的饮食摄入来维持）对于确保骨骼肌纤维的再生能力至关重要。
