Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
Molecules. 2021 Mar 5;26(5):1398. doi: 10.3390/molecules26051398.
Silica nanoparticles are a class of molecules commonly used in drug or gene delivery systems that either facilitate the delivery of therapeutics to specific drug targets or enable the efficient delivery of constructed gene products into biological systems. Some in vivo or in vitro studies have demonstrated the toxic effects of silica nanoparticles. Despite the availability of risk management tools in response to the growing use of synthetic silica in commercial products, the molecular mechanism of toxicity induced by silica nanoparticles is not well characterized. The purpose of this study was to elucidate the effects of silica nanoparticle exposure in three types of cells including human aortic endothelial cells, mouse-derived macrophages, and A549 non-small cell lung cancer cells using toxicogenomic analysis. The results indicated that among all three cell types, the TNF and MAPK signaling pathways were the common pathways upregulated by silica nanoparticles. These findings may provide insight into the effects of silica nanoparticle exposure in the human body and the possible mechanism of toxicity.
硅纳米颗粒是一类常用于药物或基因传递系统的分子，它们可以促进治疗剂递送到特定的药物靶点，或者使构建的基因产物有效地递送到生物系统中。一些体内或体外研究已经证明了硅纳米颗粒的毒性作用。尽管有风险管理工具可用于应对商业产品中合成硅的日益使用，但硅纳米颗粒诱导毒性的分子机制尚未得到很好的描述。本研究旨在使用毒理学基因组学分析阐明硅纳米颗粒暴露在三种类型的细胞中的影响，包括人主动脉内皮细胞、小鼠来源的巨噬细胞和 A549 非小细胞肺癌细胞。结果表明，在所有三种细胞类型中，TNF 和 MAPK 信号通路是硅纳米颗粒上调的共同通路。这些发现可能为了解硅纳米颗粒暴露在人体中的影响和可能的毒性机制提供线索。
