CEPED (UMR 196), Université de Paris, IRD, 75006 Paris, France.
SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, CANBIOS Team (Équipe Labellisée LIGUE 2019), Aix-Marseille University, INSERM, IRD, 13009 Marseille, France.
Int J Environ Res Public Health. 2021 Mar 5;18(5):2611. doi: 10.3390/ijerph18052611.
The COVID-19 pandemic put clinical research in the media spotlight globally. This article proposes a first measure of familiarity with and attitude toward clinical research in France. Drawing from the "Health Literacy Survey 2019" (HLS19) conducted online between 27 May and 5 June 2020 on a sample of the French adult population (N = 1003), we show that a significant proportion of the French population claimed some familiarity with clinical trials (64.8%) and had positive attitudes (72%) toward them. One of the important findings of this study is that positive attitudes toward clinical research exist side by side with a strong distancing from the pharmaceutical industry. While respondents acknowledged that the pharmaceutical industry plays an important role in clinical research (68.3%), only one-quarter indicated that they trust the industry (25.7%). Positive attitudes toward clinical trials were associated with familiarity with clinical trials (Odds Ratio, OR 2.97 [1.90-4.63]), financial difficulties (OR 0.63 [0.46-0.85]), as well as mistrust of doctors (0.48 [0.27-0.85]) and of scientists (OR 0.62 [0.38-0.99]). Although the French media provided a great deal of information on how clinical research works during the first months of the pandemic, there remains profound mistrust of the pharmaceutical industry in France. This suspicion can undermine crisis management, especially in the areas of vaccine development and preparation for future pandemics.
新冠疫情让全球的临床研究成为了媒体关注的焦点。本文提出了法国对临床研究熟悉程度和态度的初步衡量标准。本研究基于 2020 年 5 月 27 日至 6 月 5 日在法国成年人群体（N=1003）中进行的在线“2019 年健康素养调查”（HLS19）的数据，结果表明，相当一部分法国人声称对临床试验有一定的了解（64.8%），并对其持积极态度（72%）。这项研究的一个重要发现是，对临床研究的积极态度与对制药行业的强烈疏远并存。尽管受访者承认制药行业在临床研究中发挥着重要作用（68.3%），但只有四分之一的人表示信任该行业（25.7%）。对临床试验的积极态度与对临床试验的熟悉程度（优势比，OR 2.97[1.90-4.63]）、经济困难（OR 0.63[0.46-0.85]）以及对医生（OR 0.48[0.27-0.85]）和科学家（OR 0.62[0.38-0.99]）的不信任有关。尽管法国媒体在疫情的头几个月提供了大量关于临床研究如何运作的信息，但法国民众对制药行业仍存在深深的不信任。这种怀疑可能会破坏危机管理，尤其是在疫苗开发和为未来的大流行做准备方面。
