Es-Safi Imane, Mechchate Hamza, Amaghnouje Amal, Jawhari Fatima Zahra, Al Kamaly Omkulthom Mohamed, Imtara Hamada, Grafov Andriy, Bari Amina, Bousta Dalila
Laboratory of Biotechnology, Environment, Agrifood, and Health, University of Sidi Mohamed Ben Abdellah, FSDM-Fez 30050, Morocco.
Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia.
Life (Basel). 2021 Mar 5;11(3):207. doi: 10.3390/life11030207.
Depression and anxiety are widespread illnesses whose consequences on patients' social and professional lives are becoming ever more dangerous and severe. The study's objective is to explore the antidepressant-like and anxiolytic activity of the polyphenolic extract of L. as well as its antioxidant power as they were recently associated. The predictive antidepressant activity was evaluated using the forced swimming and tail suspension test in mice, a preclinical behavioral model widely used to determine the efficacy of antidepressant drugs. As for anxiolytic-like activity, two models were used, namely the light/dark chamber test to measure the animal's degree of anxiety and the open field test to evaluate both anxiolytic and locomotor activity. The tests results indicate a remarkable antidepressant and anxiolytic-like effect after oral administration of the polyphenolic fraction of and interesting antioxidant property. In the extract it has been confirmed the presence of 6 molecules belonging to polyphenols, identified with HPLC analysis. This study confirms and encourages the traditional use of the extract and appeals to further studies to understand its action mechanism.
抑郁症和焦虑症是普遍存在的疾病，它们对患者社交和职业生活的影响正变得越来越危险和严重。该研究的目的是探索L.的多酚提取物的抗抑郁样和抗焦虑活性，以及其最近被发现的抗氧化能力。使用小鼠强迫游泳和悬尾试验评估预测性抗抑郁活性，这是一种广泛用于确定抗抑郁药物疗效的临床前行为模型。至于抗焦虑样活性，则使用了两种模型，即明暗箱试验来测量动物的焦虑程度，以及旷场试验来评估抗焦虑和运动活性。测试结果表明，口服该多酚部分后具有显著的抗抑郁和抗焦虑样作用以及有趣的抗氧化特性。在提取物中，已通过高效液相色谱分析确认存在6种属于多酚的分子。这项研究证实并鼓励了该提取物的传统用途，并呼吁进行进一步研究以了解其作用机制。
