Laboratory of Biotechnology, Environment, Agri-Food and Health (LBEAS), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University (USMBA), Fez 30050, Morocco.
Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia.
Molecules. 2021 Apr 1;26(7):2009. doi: 10.3390/molecules26072009.
Depression and anxiety are major mental health problems in all parts of the world. These illnesses are associated with a number of risk factors, including oxidative stress. Psychotropic drugs of a chemical nature have demonstrated several side effects that elevated the impact of those illnesses. Faced with this situation, natural products appear to be a promising alternative. The aim of this study was to evaluate the anxiolytic and antidepressant effects of the polyphenols in vivo, as well as its correlated antioxidant properties in vitro. Anxiolytic activity of the extract (50 and 100 mg/kg) was evaluated using the open field and the light-dark chamber tests, while the antidepressant activity was evaluated using the forced swimming test. The antioxidant activity of the extract was evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical test and the FRAP (iron-reducing capacity) test. The phenolic extract showed very powerful anxiolytic and antidepressant-like effects, especially at a dose of 100 mg/kg, decreasing the depressive behavior in mice (decreased immobility time) and also the anxiolytic behavior (tendency for discovery in the center and illuminated areas) better even than those of paroxetine and bromazepam (classic drugs) concomitant with those results the extract also showed an important antioxidant capacity. These preliminary results suggest that exhibits anxiolytic and antidepressant potential for use as a complement or independent phytomedicine to treat depression and anxiety.
抑郁和焦虑是全球各地的主要心理健康问题。这些疾病与许多风险因素有关，包括氧化应激。具有化学性质的精神药物已显示出多种副作用，这些副作用加重了这些疾病的影响。面对这种情况，天然产品似乎是一种有前途的替代方法。本研究的目的是评估多酚的体内抗焦虑和抗抑郁作用，以及其体外相关的抗氧化特性。使用开阔场和明暗室测试评估提取物（50 和 100 mg/kg）的抗焦虑活性，而使用强迫游泳测试评估抗抑郁活性。通过 2,2-二苯基-1-苦基肼基（DPPH）自由基测试和 FRAP（铁还原能力）测试评估提取物的抗氧化活性。酚类提取物表现出非常强大的抗焦虑和抗抑郁样作用，尤其是在 100 mg/kg 剂量下，可降低小鼠的抑郁行为（减少不动时间），并改善焦虑行为（在中心和照明区域的探索倾向），甚至优于帕罗西汀和溴西泮（经典药物）。伴随着这些结果，提取物还显示出重要的抗氧化能力。这些初步结果表明， 具有抗焦虑和抗抑郁的潜力，可作为补充或独立的植物药用于治疗抑郁和焦虑。
