以昆虫特异性病毒为平台的抗虫媒病毒新型疫苗的研究进展
Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms.
作者信息
Carvalho Valéria L, Long Maureen T
机构信息
Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, 1945 SW 16th Ave, Gainesville, FL 32608, USA.
Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Rodovia BR-316, Km 7, s/n, Ananindeua, 67030-000 Para, Brazil.
出版信息
Vaccines (Basel). 2021 Mar 16;9(3):263. doi: 10.3390/vaccines9030263.
Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique platform for expression of arbovirus proteins, through the creation of ISV/arbovirus chimeras. Studies have shown promising results of these vaccines with several advantages over their wild-type counterparts. In this review, we discuss the current status of these potential vaccines using ISVs.
节肢动物传播病毒（虫媒病毒）是全球性病原体，在地方流行，时有局部爆发，并不断侵入新地区。针对虫媒病毒的疫苗很少；大多数针对人类的疫苗正在研发或处于临床试验阶段。昆虫特异性病毒（ISV）通过构建ISV/虫媒病毒嵌合体，为表达虫媒病毒蛋白提供了一个独特的平台。研究表明，这些疫苗取得了令人鼓舞的成果，与野生型对应疫苗相比具有若干优势。在本综述中，我们讨论了使用ISV的这些潜在疫苗的现状。
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