Bekeschus Sander
ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
Nanomaterials (Basel). 2021 Mar 22;11(3):806. doi: 10.3390/nano11030806.
Despite continuous advances in therapy, cancer remains a deadly disease. Over the past years, gas plasma technology emerged as a novel tool to target tumors, especially skin. Another promising anticancer approach are nanoparticles. Since combination therapies are becoming increasingly relevant in oncology, both gas plasma treatment and nanoparticle exposure were combined. A series of nanoparticles were investigated in parallel, namely, silica, silver, iron oxide, cerium oxide, titanium oxide, and iron-doped titanium oxide. For gas plasma treatment, the atmospheric pressure argon plasma jet kINPen was utilized. Using three melanoma cell lines, the two murine non-metastatic B16F0 and metastatic B16F10 cells and the human metastatic B-Raf mutant cell line SK-MEL-28, the combined cytotoxicity of both approaches was identified. The combined cytotoxicity of gas plasma treatment and nanoparticle exposure was consistent across all three cell lines for silica, silver, iron oxide, and cerium oxide. In contrast, for titanium oxide and iron-doped titanium oxide, significantly combined cytotoxicity was only observed in B16F10 cells.
尽管治疗方法不断进步，但癌症仍然是一种致命疾病。在过去几年中，气体等离子体技术作为一种靶向肿瘤尤其是皮肤肿瘤的新型工具出现。另一种有前景的抗癌方法是纳米颗粒。由于联合疗法在肿瘤学中变得越来越重要，因此将气体等离子体治疗和纳米颗粒暴露相结合。同时研究了一系列纳米颗粒，即二氧化硅、银、氧化铁、氧化铈、氧化钛和铁掺杂氧化钛。对于气体等离子体治疗，使用了大气压氩等离子体射流kINPen。使用三种黑色素瘤细胞系，即两种小鼠非转移性B16F0和转移性B16F10细胞系以及人转移性B-Raf突变细胞系SK-MEL-28，确定了两种方法的联合细胞毒性。对于二氧化硅、银、氧化铁和氧化铈，气体等离子体治疗和纳米颗粒暴露的联合细胞毒性在所有三种细胞系中都是一致的。相比之下，对于氧化钛和铁掺杂氧化钛，仅在B16F10细胞中观察到显著的联合细胞毒性。
