IRSI Research and Training Centre, Jakarta, Indonesia.
Faculty of Engineering and Information Technology, Swiss German University, Tangerang, Indonesia.
J Assist Reprod Genet. 2021 Jul;38(7):1627-1639. doi: 10.1007/s10815-021-02123-2. Epub 2021 Apr 3.
In vitro fertilization has been regarded as a forefront solution in treating infertility for over four decades, yet its effectiveness has remained relatively low. This could be attributed to the lack of advancements for the method of observing and selecting the most viable embryos for implantation. The conventional morphological assessment of embryos exhibits inevitable drawbacks which include time- and effort-consuming, and imminent risks of bias associated with subjective assessments performed by individual embryologists. A combination of these disadvantages, undeterred by the introduction of the time-lapse incubator technology, has been considered as a prominent contributor to the less preferable success rate of IVF cycles. Nonetheless, a recent surge of AI-based solutions for tasks automation in IVF has been observed. An AI-powered assistant could improve the efficiency of performing certain tasks in addition to offering accurate algorithms that behave as baselines to minimize the subjectivity of the decision-making process. Through a comprehensive review, we have discovered multiple approaches of implementing deep learning technology, each with varying degrees of success, for constructing the automated systems in IVF which could evaluate and even annotate the developmental stages of an embryo.
体外受精(IVF)作为治疗不孕不育的前沿方法已经有四十多年的历史了,但它的有效性仍然相对较低。这可能是因为在观察和选择最适合植入的胚胎的方法上没有取得进展。胚胎的传统形态评估存在不可避免的缺陷,包括耗时费力,以及个体胚胎学家进行主观评估所带来的潜在偏见风险。这些缺点的结合,加上时差培养箱技术的引入,被认为是导致 IVF 周期成功率较低的一个主要因素。然而,最近观察到人工智能(AI)在 IVF 中的任务自动化方面的解决方案有所增加。人工智能助手可以提高执行某些任务的效率,同时提供准确的算法作为基准,以最大程度地减少决策过程的主观性。通过全面的综述,我们发现了多种实施深度学习技术的方法,每种方法都在不同程度上取得了成功,这些方法可以构建 IVF 中的自动化系统,从而评估甚至注释胚胎的发育阶段。